Evaluation of a multicomponent programme for the management of musculoskeletal pain and depression in primary care: a cluster-randomised clinical trial (the DROP study)

BMC Psychiatry

Study Protocol

Germán López-Cortacans¹  Concepció Rambla¹  Antonia Caballero¹  Enric Aragonès²  Josep Ll. Piñol³  Jordi Miró⁴  Catarina Tomé-Pires⁴  Elisabet Sánchez-Rodríguez⁴ 

[1] Atenció Primària Camp de Tarragona; Institut Català de la Salut, Tarragona, Spain;Institut Universitari d’Investigació en Atenció Primària (IDIAP) Jordi Gol, Barcelona, Spain;Atenció Primària Camp de Tarragona; Institut Català de la Salut, Tarragona, Spain;Institut Universitari d’Investigació en Atenció Primària (IDIAP) Jordi Gol, Barcelona, Spain;Centre d’Atenció Primària de Constantí, Carrer dels Horts, 6, 43120, Tarragona, Constantí, Spain;Atenció Primària Terres de l’Ebre, Institut Català de la Salut, Tortosa, Spain;Institut Universitari d’Investigació en Atenció Primària (IDIAP) Jordi Gol, Barcelona, Spain;Chair in Pediatric Pain URV-Fundación Grünenthal and Unit for the Study and Treatment of Pain – ALGOS, Catalonia, Spain;Research Center for Behavior Assessment (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Catalonia, Spain;Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Catalonia, Spain;

关键词: Depressive disorder;    Musculoskeletal pain;    Primary health care;    Care management;    Patient education;   

DOI  :  10.1186/s12888-016-0772-2

 received in 2016-02-25, accepted in 2016-03-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundChronic musculoskeletal pain and depression are very common in primary care patients. Furthermore, they often appear as comorbid conditions, resulting in additive effect on adverse health outcomes. On the basis of previous studies, we hypothesise that depression and chronic musculoskeletal pain may benefit from an integrated management programme at primary care level. We expect positive effects on both physical and psychological distress of patients.MethodsObjective: To determine whether a new programme for an integrated approach to chronic musculoskeletal pain and depression leads to better outcomes than usual care.Design: Cluster-randomised controlled trial involving two arms: a) control arm (usual care); and b) intervention arm, where patients participate in a programme for an integrated approach to the pain-depression dyad.Settings: Primary care centres in the province of Tarragona, Catalonia, Spain,Participants: We will recruit 330 patients aged 18–80 with moderate or severe musculoskeletal pain (Brief Pain Inventory, average pain subscale ≥5) for at least 3 months, and with criteria for major depression (DSM-IV).Intervention: A multicomponent programme according to the chronic care model. The main components are care management, optimised antidepressant treatment, and a psychoeducational group action.Blind measurements: The patients will be monitored through blind telephone interviews held at 0, 3, 6 and 12 months.Outcomes: Severity of pain and depressive symptoms, pain and depression treatment response rates, and depression remission rates.Analysis: The outcomes will be analysed on an intent-to-treat basis and the analysis units will be the individual patients. This analysis will consider the effect of the study design on any potential lack of independence between observations made within the same cluster.Ethics: The protocol was approved by the Research Ethics Committee of the Jordi Gol Primary Care Research Institute (IDIAP), Barcelona, (P14/142).DiscussionThis project strengthens and improves treatment approaches for a major comorbidity in primary care. The design of the intervention takes into account its applicability under typical primary care conditions, so that if the programme is found to be effective it will be feasible to apply it in a generalised manner.Trial registrationClinicalTrials.gov: NCT02605278; Registered 28 September, 2015.

【 授权许可】

CC BY   
© Aragonès et al. 2016