No red cell alloimmunization or change of clinical outcome after using fresh frozen cancellous allograft bone for acetabular reconstruction in revision hip arthroplasty: a follow up study

BMC Musculoskeletal Disorders

Research Article

Matthias Straub¹  Falk Mittag¹  Ingmar Ipach¹  Torsten Kluba¹  Richard Schäfer² 

[1] Department of Orthopaedic Surgery, University Hospital Tuebingen, Hoppe-Seyler-Str 3, 72076, Tuebingen, Germany;Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tuebingen, Otfried-Mueller-Str 4/1, 72076, Tuebingen, Germany;

关键词: Acetabular revision;    Allograft bone;    Remodeling;    Alloimmunization;    AB0;    Rhesus;   

DOI  :  10.1186/1471-2474-13-187

 received in 2012-04-26, accepted in 2012-09-11,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPossible immunization to blood group or other antigens and subsequent inhibition of remodeling or incorporation after use of untreated human bone allograft was described previously. This study presents the immunological, clinical and radiological results of 30 patients with acetabular revisions using fresh frozen non-irradiated bone allograft.MethodsAB0-incompatible (donor-recipient) bone transplantation was performed in 22 cases, Rh(D) incompatible transplantation in 6 cases. The mean follow up of 23 months included measuring Harris hip score and radiological examination with evaluation of remodeling of the bone graft, implant migration and heterotopic ossification. In addition, all patients were screened for alloimmunization to Rh blood group antigens.ResultsCompared to the whole study group, there were no differences in clinical or radiological measurements for the groups with AB0- or Rh(D)-incompatible bone transplantation. The mean Harris Hip Score was 80.6. X-rays confirmed total remodeling of all allografts with no acetabular loosening. At follow up, blood tests revealed no alloimmunization to Rh blood group donor antigens.ConclusionsThe use of fresh frozen non-irradiated bone allograft in acetabular revision is a reliable supplement to reconstruction. The risk of alloimmunization to donor-blood group antigens after AB0- or Rh-incompatible allograft transplantation with a negative long-term influence on bone-remodeling or the clinical outcome is negligible.

【 授权许可】

Unknown   
© Mittag et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.