Varicella susceptibility and transmission dynamics in Slovenia

BMC Public Health

Research Article

Maja Sočan¹  Nataša Berginc²  Jaro Lajovic³ 

[1] Centre for Communicable Diseases, National Institute of Public Health of Republic of Slovenia, Trubarjeva 2, 1000, Ljubljana, Slovenia;Laboratory for virology, Centre for Communicable Diseases, National Institute of Public Health of Republic of Slovenia, Bohoričeva 15, 1000, Ljubljana, Slovenia;Rho Sigma Research & Statistics, Topniška 45, 1000, Ljubljana, Slovenia;

关键词: Herpes Zoster;    Varicella Vaccine;    Varicella Vaccination;    Herpes Zoster Incidence;    Varicella Case;   

DOI  :  10.1186/1471-2458-10-360

 received in 2009-11-30, accepted in 2010-06-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundA cross-sectional, age-stratified study was conducted to determine varicella-zoster seroprevalence and force of infection in Slovenia.Methods3689 serum samples were tested for VZV IgG antibodies with an enzyme immunoassay. Semiparametric and parametric modelling were used to estimate the force of infection.ResultsOverall, 85.6% of serum samples were seropositive. Age-specific prevalence rose rapidly in preschool children and over 90% of 8 years old tested positive for VZV. However, 2.8% of serum samples among women of childbearing age were seronegative. Semiparametric modelling yielded force of infection estimates of 0.182 (95% CI 0.158-0.206), 0.367 (95% CI 0.285-0.448) and 0.008 (95% CI 0.0-0.032) for age groups 0.5- < 6, 6-11 and ≥12 years, respectively, and 0.175 (95% CI 0.147-0.202), 0.391 (95% CI 0.303-0.480) and 0.025 (95% CI 0.003-0.046) for age groups 0.5- < 5, 5-9 and ≥10 years, respectively.ConclusionsRegardless of the age grouping used, the highest transmission occurred in children in their first years of school.

【 授权许可】

CC BY   
© Sočan et al; licensee BioMed Central Ltd. 2010