Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

BMC Cancer

Research Article

Matthias Pfeiffer¹  Rupert Handgretinger¹  Annika Erbacher¹  Markus Mezger¹  Karin Melanie Cabanillas Stanchi¹  Peter Lang¹  Michaela Döring¹  Judith Feucht¹  Ingo Müller² 

[1] Department I – General Paediatrics, Hematology/Oncology, University Hospital Tuebingen, Children’s Hospital, Hoppe-Seyler-Str. 1, 72076, Tuebingen, Germany;Department of Paediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Center for Obstetrics and Paediatrics, Martinistraße 52, 20246, Hamburg, Germany;

关键词: Hematopoietic Stem Cell Transplantation;    Acute GvHD;    Autologous Hematopoietic Stem Cell Transplantation;    Pediatric Oncology Patient;    Intestinal GvHD;   

DOI  :  10.1186/s12885-015-1616-z

 received in 2014-08-25, accepted in 2015-08-21,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundVeno-occlusive disease, Graft-versus-Host disease, invasive or localized bacterial, viral and fungal infections are known as adverse events after hematopoietic stem cell transplantation representing the major cause for morbidity and mortality. Detection and differentiation of these adverse events are based on clinical symptoms and routine measurements of laboratory parameters.MethodsTo identify the role of cytokines as a possible complication-marker for adverse events, 61 consecutive pediatric patients with a median age of 7.0 years who underwent hematopoietic stem cell transplantation were enrolled in this single-center retrospective study. Interleukin-1 beta (IL-1β), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α serum (TNF-α) levels were regularly assessed after transplantation and during transplantation related adverse events.ResultsVeno-occlusive disease was accompanied by a significant increase in levels of IL-6, IL-8 and TNF-α.Graft-versus-Host disease was associated with a significant increase of IL-10, sIL-2R, IL-6 and TNF-α, depending on the respective stage or grade. Cytokine IL-6 enabled a significant differentiation between sepsis and fungemia, sepsis and viremia, and sepsis and bacteremia. Moreover, cytokine IL-8 enabled a significant differentiation between sepsis and viremia, sepsis and bacteremia, and bacteremia and viremia whereas IL-10 made a distinction between sepsis and viremia possible.ConclusionThe data demonstrate that proinflammatory cytokines might be putative indicators for early detection and differentiation of post-transplant adverse events and may allow prompt and adequate clinical intervention. Prospective clinical trials are needed to evaluate these findings.

【 授权许可】

CC BY   
© Döring et al. 2015