Elevated expression of periostin in diabetic cardiomyopathy and the effect of valsartan

BMC Cardiovascular Disorders

Research Article

Jun Guan¹  Hong-Yan Dai¹  Wen-Qi Liu²  Ming-Qing Xing³  Chang-Qing Jiang⁴  Yue Shi⁵  Xue-Ying Tan⁶ 

[1] Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China;Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China;Qingdao University Medical College, Qingdao, Shandong, China;Key Laboratory of cellular transplantation , Chinese Ministry of Public Health, Qingdao Municipal Hospital, Qingdao, Shandong, China;Department of Clinical laboratory, Qingdao Municipal Hospital, Qingdao, Shandong, China;Department of pathology department, Qingdao Municipal Hospital, Qingdao, Shandong, China;Qingdao University Medical College, Qingdao, Shandong, China;Qingdao University Medical College, Qingdao, Shandong, China;Key Laboratory of cellular transplantation , Chinese Ministry of Public Health, Qingdao Municipal Hospital, Qingdao, Shandong, China;

关键词: Valsartan;    Cardiac Remodel;    Diabetic Cardiomyopathy;    Hematoxylin Eosin;    Periostin Expression;   

DOI  :  10.1186/s12872-015-0084-3

 received in 2015-02-15, accepted in 2015-08-10,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPeriostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin in left ventricular remodeling of streptozototin (STZ)-induced diabetic rats. The aim of the present study was to observe the expression of periostin in Wistar rat’s myocardium of diabetic cardiomyopathy (DCM) and the effect of valsartan on it.MethodsImmunohistochemistry, real-time polymerase chain reaction, and Western blot analysis were used to determine the degree of expression and location of periostin, transforming growth factor (TGF)-β1, TGF-β1 type II receptor (TGF-β1 R II), and Type I and III collagens in the myocardium of STZ-induced diabetic rats.ResultsPeriostin, TGF-β1, TGF-β1 R II, and Type I and III collagens were significantly increased in the myocardium of diabetic rats compared with control group on both messenger ribonucleic acid and protein levels. In addition, diabetic rats treated with valsartan could have reduced expression of periostin and improved cardiac remodeling of DCM.ConclusionsPeriostin may play a crucial role in cardiac remodeling and myocardial interstitial fibrosis process of DCM and it could be one of the important mechanisms for valsartan to improve the ventricular remodeling of DCM.

【 授权许可】

CC BY   
© Guan et al. 2015