Level, causes, and risk factors of stillbirth: a population-based case control study from Chandigarh, India

BMC Pregnancy and Childbirth

Research Article

Madhu Gupta¹  Ariarathinam Newtonraj¹  Rajesh Kumar¹  Manmeet Kaur¹ 

[1] Department of Community Medicine, School of Public Health, Post Graduate Institute of Medical Education and Research, 160 012, Chandigarh, India;

关键词: Stillbirth;    Fetal death;    Case control;    Capture and recapture;    Risk factors;    India;    Pregnancy outcome;    Incidence;   

DOI  :  10.1186/s12884-017-1557-4

 received in 2015-07-30, accepted in 2017-11-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGlobally, India ranks first in the absolute number of stillbirths. Hence, the level, causes, and risk factors of stillbirths were estimated to facilitate designing of prevention strategy.MethodsCapture and recapture method was used to identify 301 stillbirths from 1st July 2013 to 31st August 2014 in Chandigarh Union Territory of India. Verbal autopsies (n = 181) were done at household level to identify causes of stillbirths. Risk factors were determined using case-control approach. Women who had a stillbirth in the past 3 months were enrolled as cases (n = 181) and those who had live-birth in same neighbourhood were included as controls (n = 181). Statistical differences in the distribution of characteristics of cases and controls were tested by t test and chi square test respectively for quantitative and categorical variables. In logistic regression models adjusted odds ratios (aOR) and 95% confidence intervals (CIs) were estimated for various risk factors.ResultsStillbirth rate was estimated to be 16/1000 birth. Antepartum causes were more common (68%) than intrapartum causes (32%). Among maternal conditions, hypertension (18.2%) and chorio-amnionitis (13.8%), and among foetal conditions, growth restriction (19.9%) and congenital anomalies (18.8%) were the leading causes. In about half of the stillbirths foetal (48%) and maternal (44.7%) causes were unidentifiable. Risk factors of stillbirths were: higher maternal age (aOR 1.1, 95%CI 1.0–1.2), vaginal delivery (aOR 8.1, 95%CI 2.6–26), induced labour (aOR 2.6, 95%CI 1.5–4.5), green or light brown liquor (aOR 2.0, 95%CI 1.1–3.8), preterm delivery (aOR 6.4, 95%CI 3.7–11) and smaller household size (aOR 1.2, 95% CI 1.1–1.3).ConclusionsStillbirth rate was high in Chandigarh Union Territory of India. Major causes and risk factors amenable to interventions were infections, hypertension, congenital malformations, foetal growth restriction, pre-maturity and household size. Therefore, better maternity ante-natal and intra-natal care is required to achieve a single digit stillbirth rate.

【 授权许可】

CC BY   
© The Author(s). 2017