Evaluating the impact of cannabis use on thalamic connectivity in youth at clinical high risk of psychosis

BMC Psychiatry

Research Article

Kristina Lyngberg¹  Larry J. Seidman²  Kristin S. Cadenhead³  Lisa Buchy⁴  Jean Addington⁵  Diana O. Perkins⁶  Scott W. Woods⁷  Thomas H. McGlashan⁷  Alan Anticevic⁷  Barbara A. Cornblatt⁸  Ming T. Tsuang⁸  Tyrone D. Cannon⁹  Carrie E. Bearden^1,10  Elaine F. Walker^1,11  Daniel H. Mathalon^1,12 

[1] Department of Neuroscience, Faculty of Science, University of Calgary, Alberta, Canada;Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, USA;Department of Psychiatry, UCSD, La Jolla, CA, USA;Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada;Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada;Mathison Centre for Mental Health Research and Education, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Alberta, Canada;Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA;Department of Psychiatry, Yale University, New Haven, CT, USA;Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA;Department of Psychology, Yale University, New Haven, CT, USA;Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles, CA, USA;Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, USA;University of California, San Francisco, San Francisco, CA, USA;

关键词: Cannabis;    Clinical high risk;    Functional connectivity;    Resting state functional magnetic resonance imaging;    Psychosis;    Schizophrenia;    Thalamus;   

DOI  :  10.1186/s12888-015-0656-x

 received in 2015-07-07, accepted in 2015-10-19,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundDisruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psychosis on thalamic dysconnectivity is poorly understood. We tested whether thalamic dysconnectivity is related to patterns of cannabis use in a CHR sample.Methods162 CHR and 105 control participants were assessed on cannabis use severity, frequency, and age at onset of first use as part of the North American Prodrome Longitudinal Study and completed resting-state fMRI scans. Whole-brain thalamic functional connectivity maps were generated using individual subjects’ anatomically defined thalamic seeds.ResultsThalamic connectivity did not significantly correlate with current cannabis use severity or frequency in either CHR or controls. In CHR cannabis users, a significant correlation emerged between attenuated thalamic connectivity with left sensory/motor cortex and a younger age at onset of cannabis use. CHR who used cannabis before age 15 did not differ on thalamic connectivity as compared to CHR who used after age 15 or CHR who were cannabis naïve. No group differences in thalamic connectivity emerged when comparing CHR separated by moderate/high use frequency, low-frequency or cannabis naïve.ConclusionsAlthough a younger age at onset of cannabis use may be associated with disrupted thalamo-cortical coupling, cannabis use does not appear to be an identifying characteristic for thalamic connectivity in CHR with moderate/high use frequency compared to low-frequency users or CHR who are cannabis naïve.

【 授权许可】

CC BY   
© Buchy et al. 2015