Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial

BMC Geriatrics

Study Protocol

Nalin A Singh¹  Bernhard T Baune²  Nasim Foroughi³  Dominique Williamson³  Michael K Baker³  Nidhi Jain³  Yi Wang³  Guy C Wilson³  Maria A Fiatarone Singh⁴  Chao Suo⁵  Nicola J Gates⁵  Perminder S Sachdev⁶  Henry Brodaty⁷  Michael Valenzuela⁸ 

[1] Balmain Hospital, 2041, Balmain, NSW, Australia;Royal Prince Alfred Hospital, 2050, Camperdown, NSW, Australia;Discipline of Psychiatry, School of Medicine, University of Adelaide, 5005, Adelaide, SA, Australia;Exercise Health and Performance Faculty Research Group, Sydney Medical School, The University of Sydney, 2141, Lidcombe, NSW, Australia;Exercise Health and Performance Faculty Research Group, Sydney Medical School, The University of Sydney, 2141, Lidcombe, NSW, Australia;Hebrew Senior Life, Boston, MA, and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 02130, Boston, MA, USA;School of Psychiatry, University of New South Wales, 2031, Randwick, NSW, Australia;School of Psychiatry, University of New South Wales, 2031, Randwick, NSW, Australia;Brain and Aging Research Program, University of New South Wales, 2031, Randwick, NSW, Australia;Neuropsychiatric Institute, Prince of Wales Hospital, 2031, Randwick, NSW, Australia;School of Psychiatry, University of New South Wales, 2031, Randwick, NSW, Australia;Brain and Aging Research Program, University of New South Wales, 2031, Randwick, NSW, Australia;Primary Dementia Collaborative Research Centre, University of New South Wales, 2031, Randwick, NSW, Australia;School of Psychiatry, University of New South Wales, 2031, Randwick, NSW, Australia;Brain and Aging Research Program, University of New South Wales, 2031, Randwick, NSW, Australia;Regenerative Neuroscience Group, School of Psychiatry, University of New South Wales, 2031, Randwick, NSW, Australia;

关键词: Cognitive Training;    Clinical Dementia Rate;    Progressive Resistance Training;    Symbol Digit Modality Test;    Global Cognitive Function;   

DOI  :  10.1186/1471-2318-11-19

 received in 2011-02-11, accepted in 2011-04-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and functional independence in older adults with early cognitive impairment: Study of Mental and Regular Training (SMART). Our secondary aim is to quantify the differential adaptations to these interventions in terms of brain morphology and function, cardiovascular and metabolic function, exercise capacity, psychological state and body composition, to identify the potential mechanisms of benefit and broader health status effects.MethodsSMART is a double-blind randomized, double sham-controlled trial. One hundred and thirty-two community-dwelling volunteers will be recruited. Primary inclusion criteria are: at risk for cognitive decline as defined by neuropsychology assessment, low physical activity levels, stable disease, and age over 55 years. The two active interventions are computerized CT and whole body, high intensity PRT. The two sham interventions are educational videos and seated calisthenics. Participants are randomized into 1 of 4 supervised training groups (2 d/wk × 6 mo) in a fully factorial design. Primary outcomes measured at baseline, 6, and 18 months are the Alzheimer's Disease Assessment Scale (ADAS-Cog), neuropsychological test scores, and Bayer Informant Instrumental Activities of Daily Living (B-IADLs). Secondary outcomes are psychological well-being, quality of life, cardiovascular and musculoskeletal function, body composition, insulin resistance, systemic inflammation and anabolic/neurotrophic hormones, and brain morphology and function via Magnetic Resonance Imaging (MRI) and Spectroscopy (fMRS).DiscussionSMART will provide a novel evaluation of the immediate and long term benefits of CT, PRT, and combined CT and PRT on global cognitive function and brain morphology, as well as potential underlying mechanisms of adaptation in older adults at risk of further cognitive decline.Trial RegistrationAustralia and New Zealand Clinical Trials Register (ANZCTR): ANZCTRN12608000489392

【 授权许可】

CC BY   
© Gates et al; licensee BioMed Central Ltd. 2011