Diagnostic outcome of ureteroscopy in urothelial carcinoma of the upper urinary tract: Incidence of later cancer detection and its risk factors after the first examination

BMC Urology

Research Article

Kanako Hatanaka¹  Toru Harabayashi²  Takashige Abe³  Sachiyo Murai³  Satoru Maruyama³  Naoto Miyajima³  Norihiro Murahashi³  Nobuo Shinohara³  Kunihiko Tsuchiya³  Katsuya Nonomura³  Ataru Sazawa⁴ 

[1] Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan;Department of Urology, Hokkaido Cancer Center, Sapporo, Japan;Department of Urology, Hokkaido University Graduate School of Medicine, North-15, West-7, North Ward, 060-8638, Sapporo, Japan;Department of Urology, Obihiro-Kosei General Hospital, Obihiro, Japan;

关键词: Bladder Cancer;    Cancer Detection;    Urothelial Carcinoma;    Diagnostic Outcome;    Ureteral Injury;   

DOI  :  10.1186/s12894-015-0086-6

 received in 2015-01-28, accepted in 2015-08-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundTo determine the incidence of later cancer detection and its risk factors after the first diagnostic ureteroscopy.MethodsOne hundred and sixty-six patients undergoing diagnostic ureteroscopy based on the suspicion of urothelial carcinoma of the upper urinary tract (UC of the UUT) between 1995 and 2012 were included. We examined the diagnostic outcome of the initial ureteroscopy. Thereafter, we collected follow-up data on patients who had not been diagnosed with UC of the UUT at the first examination, and evaluated the incidence of later cancer detection and its risk factors using Cox hazard models.ResultsOf the 166 patients, 76 (45.8 %) were diagnosed with UC of the UUT at the first diagnostic ureteroscopy. The remaining 90 (54.2 %) were diagnosed with other malignancies (n = 22), non-malignant disorders (n = 18), or without disorders (n = 50). Of these 90 patients, follow-up data were available in 65 patients (median: 41 months, range: 3–170). During the follow-up, carcinoma was detected in 6 patients (6/65, 9.2 %) at a median of 43.5 months (range: 10–59). Episodes of gross hematuria (p = 0.0048) and abnormal cytological findings (p = 0.0335) during the follow-up and a male sex (p = 0.0316) were adverse risk factors.ConclusionLater cancer detection of UC of the UUT was not uncommon after the first examination. The risk analysis revealed the aforementioned characteristics.

【 授权许可】

CC BY   
© Murahashi et al. 2015