Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis

BMC Gastroenterology

Research Article

Ryoji Miyahara¹  Yoshiki Hirooka¹  Masanao Nakamura²  Osamu Maeda²  Daisuke Ishikawa²  Osamu Watanabe²  Kazuhiro Ishiguro²  Naoki Ohmiya²  Takafumi Ando²  Nobuyuki Miyake²  Hidemi Goto³  Emad M El-Omar⁴ 

[1] Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan;Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan;Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan;Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan;Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK;

关键词: Ulcerative Colitis;    Bowel Wall;    Ulcerative Colitis Patient;    Homogeneous Type;    Tissue Strain;   

DOI  :  10.1186/1471-230X-11-29

 received in 2010-11-09, accepted in 2011-03-31,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundReal-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.MethodsThirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.ResultsOn EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy.ConclusionsIn this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.

【 授权许可】

Unknown   
© Ishikawa et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.