Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China

BMC Cancer

Research Article

Bing-Jian Feng¹  Shugart Yin Yao²  Hai-De Qin³  Li-Zhen Chen³  Qi-Sheng Feng³  Wen-Sheng Liu³  Xiang-Yu Luo³  Yi-Xin Zeng³  Jin-Xin Bei³  Wei-Hua Jia⁴  Hong-Lian Ruan⁵ 

[1] Department of Dermatology, University of Utah School of Medicine, 84132, Salt Lake City, UT, USA;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA;State Key Laboratory of Oncology in Southern China, 510060, Guangzhou, China;Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China;State Key Laboratory of Oncology in Southern China, 510060, Guangzhou, China;Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China;School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China;State Key Laboratory of Oncology in Southern China, 510060, Guangzhou, China;School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China;

关键词: Guangdong Province;    Fresh Fruit;    Herbal Plant;    Intake Frequency;    Preserve Food;   

DOI  :  10.1186/1471-2407-10-446

 received in 2010-01-15, accepted in 2010-08-20,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundNasopharyngeal carcinoma (NPC) is rare in most parts of the world but is a common malignancy in southern China, especially in Guangdong. Dietary habit is regarded as an important modifier of NPC risk in several endemic areas and may partially explain the geographic distribution of NPC incidence. In China, rapid economic development during the past few decades has changed the predominant lifestyle and dietary habits of the Chinese considerably, requiring a reassessment of diet and its potential influence on NPC risk in this NPC-endemic area.MethodsTo evaluate the association between dietary factors and NPC risk in Guangdong, China, a large-scale, hospital-based case-control study was conducted. 1387 eligible cases and 1459 frequency matched controls were recruited. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated using a logistic regression model, adjusting for age, sex, education, dialect, and habitation household type.ResultsObservations made include the following: 1) consumption of canton-style salted fish, preserved vegetables and preserved/cured meat were significantly associated with increased risk of NPC, with enhanced odds ratios (OR) of 2.45 (95% CI: 2.03-2.94), 3.17(95% CI: 2.68-3.77) and 2.09 (95% CI: 1.22-3.60) respectively in the highest intake frequency stratum during childhood; 2) consumption of fresh fruit was associated with reduced risk with a dose-dependent relationship (p = 0.001); and 3) consumption of Canton-style herbal tea and herbal slow-cooked soup was associated with decreased risk, with ORs of 0.84 (95% CI: 0.68-1.03) and 0.58 (95% CI: 0.47-0.72) respectively in the highest intake frequency stratum. In multivariate analyses, these associations remained significant.ConclusionsIt can be inferred that previously established dietary risk factors in the Cantonese population are still stable and have contributed to the incidence of NPC.

【 授权许可】

CC BY   
© Jia et al; licensee BioMed Central Ltd. 2010