San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats

BMC Complementary and Alternative Medicine

Research Article

Wei-Wen Kuo¹  Viswanadha Vijaya Padma²  Chia-Yao Shen³  Yu-Lan Yeh⁴  Yueh-Min Lin⁴  Hsi-Hsien Hsu⁵  Wei-Jen Ting⁶  Chih-Yang Huang⁷  Chung-Ho Chang⁸  Yuhsin Tsai⁹ 

[1] Department of Biological Science and Technology, China Medical University, 40402, Taichung, Taiwan;Department of Biotechnology, Bharathiar University, 641 046, Coimbatore, India;Department of Nursing, MeiHo University, 91201, Pingtung, Taiwan;Department of Pathology, Changhua Christian Hospital, 50006, Changhua, Taiwan;Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, 35664, Miaoli, Taiwan;Division of Colorectal Surgery, Mackay Memorial Hospital, 10449, Taipei, Taiwan;Graduate Institute of Basic Medical Science, China Medical University and Hospital, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Graduate Institute of Basic Medical Science, China Medical University and Hospital, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;School of Chinese Medicine, China Medical University, No. 91 Hsueh-Shih Road, 40402, Taichung, Taiwan;Department of Health and Nutrition Biotechnology, Asia University, 41354, Taichung, Taiwan;Institute of Cellular and System Medicine, National Health Research Institutes, 35053, Zhunan Town, Taiwan;School of Chinese Medicine, China Medical University, No. 91 Hsueh-Shih Road, 40402, Taichung, Taiwan;

关键词: San Huang Shel Shin Tang (SHSST);    Beta-cyclodextrin;    Silymarin;    CCl;    Liver protection;   

DOI  :  10.1186/s12906-016-1127-8

 received in 2015-04-14, accepted in 2016-05-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSan Huang Shel Shin Tang (SHSST) is a traditional herbal decoction used as a hepato-protective agent and is composed of Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (2:1:1 w/w). Beta-cyclodextrin (β-CD) modification may potentially increase the solubility and spectral properties of SHSST.MethodsIn this research, the hepato-protective effects of unmodified SHSST, β-CD modified SHSST complex (SHSSTc) and silymarin were evaluated in carbon tetrachloride (CCl4) induced acute hepatotoxicity in rats.ResultsSHHSTc (40 mg/kg/day) and silymarin (100 mg/kg/day) both decreased the CCl4-induced cirrhosis pathway-related transforming growth factor beta (TGF-β) and apoptosis pathway-related caspase-8 protein expressions, but SHSST (40 mg/kg/day) did not reduce TGF-β and caspase-8 significantly . Moreover, SHHSTc (40 mg/kg/day) enhanced the activation of insulin-like growth factor 1 receptor (IGF1R) mediated survival pathway than the silymarin (100 mg/kg/day) to protect the liver from damage induced by CCl4.Conclusionsβ-CD modification promotes hepato-protective effects of SHSST and reduces the required-dosage of the SHSST.

【 授权许可】

CC BY   
© Yeh et al. 2016