Chemerin and CMKLR1 expression in human arteries and periadventitial fat: a possible role for local chemerin in atherosclerosis?

BMC Cardiovascular Disorders

Research Article

Sofia G Spiroglou¹  John N Varakis¹  Helen H Papadaki¹  Christos G Kostopoulos¹  Efstratios Apostolakis² 

[1] Department of Anatomy, School of Medicine, University of Patras, 26500, Rio Patras, Greece;Department of Cardiac Surgery, University Hospital of Ioannina, School of Medicine, University of Ioannina, 45500, Ioannina, Greece;

关键词: Periadventitial adipose tissue;    Chemerin;    CMKLR1;    Atherosclerosis;    Coronary arteries;    Aorta;   

DOI  :  10.1186/1471-2261-14-56

 received in 2013-11-05, accepted in 2014-04-25,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundDepending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose tissue function and metabolism, acting in autocrine, paracrine and endocrine manners. We investigated the protein expression of chemerin and its receptor, CMKLR1, in human aortas, coronary vessels and the respective periadventitial adipose tissue and correlated their expression with the presence of atherosclerosis.MethodsImmunohistochemistry for chemerin and CMKLR1 was performed on human aortic and coronary artery samples including the periadventitial adipose tissue. Aortic and coronary atherosclerotic lesions were assessed using the AHA classification.ResultsChemerin immunopositivity was noticed in both periadventitial fat depots, in vascular smooth muscle cells and foam cells in atherosclerotic lesions. Periadventitial fat and foam cell chemerin immunopositivity was statistically significantly correlated with the severity of atherosclerosis in both locations. CMKLR1 was expressed in vascular smooth muscle cells and foam cells in aortic and coronary vessels with atherosclerotic lesions. CMKLR1 immunostaining in foam cells was statistically significantly correlated with aortic atherosclerosis.ConclusionsOur results lend some support to a presumable role of locally produced chemerin in the progression of atherosclerotic lesions, possibly acting through its CMKLR1 receptor. Further research will elucidate the role of chemerin signaling in atherosclerosis.

【 授权许可】

CC BY   
© Kostopoulos et al.; licensee BioMed Central Ltd. 2014