Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease

BMC Pulmonary Medicine

Research Article

Catherine Englebretsen¹  Dilys Lai¹  Nicholas S Hopkinson²  Michael I Polkey²  Caroline Jolley²  Fran Dyer²  Farid Bazari²  Lizzie Flude² 

[1] Chelsea and Westminster NHS Foundation Trust, 369, Fulham Rd, SW10 9NH, London, UK;The NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, SW3 6NP, London, UK;

关键词: Exercise Capacity;    Acute Exacerbation;    Pulmonary Rehabilitation;    Chronic Respiratory Disease;    Primary Ciliary Dyskinesia;   

DOI  :  10.1186/1471-2466-11-58

 received in 2011-06-06, accepted in 2011-12-16,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundNon-invasive ventilation (NIV) can increase exercise tolerance, reduce exercise induced desaturation and improve the outcome of pulmonary rehabilitation in patients with chronic respiratory disease. It is not known whether it can be applied to increase exercise capacity in patients admitted with non-hypercapnic acute exacerbations of COPD (AECOPD). We investigated the acceptability and feasibility of using NIV for this purpose.MethodsOn a single occasion, patients admitted with an acute exacerbation of chronic respiratory disease who were unable to cycle for five minutes at 20 watts attempted to cycle using NIV and their endurance time (Tlim) was recorded. To determine feasibility of this approach in clinical practice patients admitted with AECOPD were screened for participation in a trial of regular NIV assisted rehabilitation during their hospital admission.ResultsIn 12 patients tested on a single occasion NIV increased Tlim from 184(65) seconds to 331(229) seconds (p = 0.04) and patients desaturated less (median difference = 3.5%, p = 0.029). In the second study, 60 patients were admitted to hospital during a three month period of whom only 18(30)% were eligible to participate and of these patients, only four (7%) consented to participate.ConclusionNIV improves exercise tolerance in patients with acute exacerbations of chronic respiratory disease but the applicability of this approach in routine clinical practice may be limited.Trial registrationhttp://www.controlled-trials.com/ISRCTN35692743

【 授权许可】

Unknown   
© Dyer et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.