Impact of valvular heart disease on activities of daily living of nonagenarians: the leiden 85-plus study a population based study

BMC Geriatrics

Research Article

Victoria Delgado¹  Rudi G Westendorp¹  Eduard R Holman¹  Jeroen J Bax¹  Gerard J Blauw²  Thomas van Bemmel²  Jacobijn Gussekloo³ 

[1] Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300, Leiden, RC, The Netherlands;Departments of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300, Leiden, RC, The Netherlands;Departments of Public health and Primary Care, Leiden University Medical Center, PO Box 9600, 2300, Leiden, RC, The Netherlands;

关键词: Aortic Stenosis;    Mitral Regurgitation;    Aortic Regurgitation;    Valvular Heart Disease;    Systolic Left Ventricular Function;   

DOI  :  10.1186/1471-2318-10-17

 received in 2009-04-27, accepted in 2010-04-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundData on the prevalence of valvular heart disease in very old individuals are scarce and based mostly on in-hospital series. In addition, the potential detrimental effect of valvular heart disease on the activities of daily living is unknown. The present study evaluated the prevalence of significant valvular heart disease and the impact of valvular heart disease on the activities of daily living in community dwelling nonagenarians. Nested within the Leiden 85-plus study, a population based follow-up study of the oldest old, a sample of 81 nonagenarians was recruited.MethodsThe left ventricular (LV) dimensions, function and the presence and severity of heart valvular disease were evaluated by echocardiography. Significant valvular heart disease included any mitral or aortic stenosis severity, moderate or severe mitral regurgitation, moderate or severe aortic regurgitation and moderate or severe tricuspid regurgitation. Activities of daily living were assessed using the Groningen Activity Restriction Scale (GARS).ResultsLV cavity diameters (end-diastolic diameter 47 ± 8 mm, end-systolic diameter 30 ± 8 mm) and systolic LV function (LV ejection fraction 66 ± 13%) were within normal for the majority of the participants. Significant valvular disease was present in 57 (70%) individuals, with mitral regurgitation and aortic regurgitation as the most frequent valve diseases (49% and 28% respectively). The GARS score between individuals with and without significant valvular heart disease was similar (36.2 ± 9.2 vs. 34.4 ± 13.2, p = 0.5).ConclusionsNonagenarian, outpatient individuals have a high prevalence of significant valvular heart disease. However, no relation was observed between the presence of significant valvular heart disease and the ability to perform activities of daily living.

【 授权许可】

CC BY   
© van Bemmel et al; licensee BioMed Central Ltd. 2010