Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer

BMC Palliative Care

Research Article

Hiroshi Soeda¹  Keigo Komine¹  Hiroyuki Shibata¹  Kazunori Otsuka¹  Hiroo Imai¹ 

[1] Department of Clinical Oncology, Graduate School of Medicine, Akita University, Hodo 1-1-1, Akita, Akita, Japan;

关键词: Taste alteration;    Dysgeusia;    Quality of life;    Oral 5-fluorouracil analogs;    Paper test strip;   

DOI  :  10.1186/1472-684X-12-38

 received in 2013-05-26, accepted in 2013-10-23,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundAlthough dysgeusia is a common adverse event in chemotherapy patients; it has not been evaluated using objective methods, and its prevalence and frequency have not been quantified.MethodsSalt-impregnated taste strips were used to objectively assess dysgeusia in patients receiving chemotherapy at Akita University (n = 38) and those off chemotherapy (n = 9). Participant characteristics, and ongoing and previous chemotherapies were evaluated, and their associations with dysgeusia analyzed.ResultsDysgeusia developed in 38.8% (14/38) of chemotherapy patients, and was most prevalent in patients receiving 5-fluorouracil (5-FU) or its oral analogs (48.1%, 13/27). Particularly, dysgeusia developed in 55.6% (10/18) of patients receiving oral 5-FU analogs; however, prevalence in patients receiving and off chemotherapy was not significantly different. Patients aged ≥70 years also tended to experience dysgeusia (75.0%, 6/8).ConclusionsAssociation with dysgeusia may be higher for some chemotherapeutic drugs. Dysgeusia should be routinely assessed in chemotherapy patients with objective methods such as paper strips; interventions for its prevention may be required.

【 授权许可】

Unknown   
© Imai et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.