Prospective, randomized comparison of gadopentetate and gadobutrol to assess chronic myocardial infarction applying cardiovascular magnetic resonance

BMC Medical Imaging

Research Article

Daniel Messroghli¹  Ralf Wassmuth²  Florian von Knobelsdorff-Brenkenhoff²  Johannes Schüler²  Andre Rudolph²  Jeanette Schulz-Menger²  Julius Traber² 

[1] Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;Working Group CMR, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125, Berlin, Germany;Dept. of Cardiology and Nephrology, HELIOS-Kliniken Berlin Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany;

关键词: Cardiovascular Magnetic Resonance;    Contrast media;    Gadobutrol;    Gd-DTPA;    Chronic myocardial infarction;    Late gadolinium enhancement;   

DOI  :  10.1186/s12880-015-0099-3

 received in 2015-05-26, accepted in 2015-11-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundWe hypothesized that the contrast medium gadobutrol is not inferior compared to Gd-DTPA in identifying and quantifying ischemic late gadolinium enhancement (LGE), even by using a lower dose.MethodsWe prospectively enrolled 30 patients with chronic myocardial infarction as visualized by LGE during clinical routine scan at 1.5 T with 0.20 mmol/kg Gd-DTPA. Participants were randomized to either 0.15 mmol/kg gadobutrol (group A) or 0.10 mmol/kg gadobutrol (group B). CMR protocol was identical in both exams.LGE was quantified using a semiautomatic approach. Signal intensities of scar, remote myocardium, blood and air were measured. Signal to noise (SNR) and contrast to noise ratios (CNR) were calculated.ResultsSignal intensities were not different between Gd-DTPA and gadobutrol in group A, whereas significant differences were detected in group B. SNR of injured myocardium (53.5+/−21.4 vs. 30.1+/−10.4, p = 0.0001) and CNR between injured and remote myocardium (50.3+/−20.3 vs. 27.3+/−9.3, p < 0.0001) were lower in gadobutrol. Infarct size was lower in both gadobutrol groups compared to Gd-DTPA (group A: 16.8+/−10.2 g vs. 12.8+/−6.8 g, p = 0.03; group B: 18.6+/−12.0 g vs. 14.0+/−9.9 g, p = 0.0016).ConclusionsTaking application of 0.2 mmol/kg Gd-DTPA as the reference, the delineation of infarct scar was similar with 0.15 mmol/kg gadobutrol, whereas the use 0.10 mmol/kg gadobutrol led to reduced tissue contrast.Trial registrationThe study had been registered under EudraCT Number: 2010-020775-22. Registration date: 2010.08.10

【 授权许可】

CC BY   
© Rudolph et al. 2015