Case report: term birth after fertility-sparing treatments for stage IB1 small cell neuroendocrine carcinoma of the cervix

BMC Women's Health

Case Report

Ya-Min Cheng¹  Geok Huey New¹  Yu-Fang Huang¹  Cheng-Yang Chou¹  Pei-Ying Wu¹  Hung-Wen Tsai²  Chun-Ting Chiang² 

[1] Department of Obstetrics & Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng-Li Rd. Northern District, 70403, Tainan, Taiwan;Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng-Li Rd. Northern District, 70403, Tainan, Taiwan;

关键词: Fertility-sparing;    Small cell neuroendocrine carcinoma;    Cervical carcinoma;    Radical trachelectomy;    Chemotherapy;    Pregnancy and delivery;    Case report;   

DOI  :  10.1186/s12905-017-0404-0

 received in 2016-08-17, accepted in 2017-07-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAdvances in cervical cancer management for childbearing women have led to less radical approaches. Use of fertility-sparing treatment to treat small cell neuroendocrine carcinoma (SCNEC) is challenging owing to the aggressive nature of the disease, even in early stage disease.Case presentationA 25-year-old nulligravida woman presented with malodorous vaginal discharge and was diagnosed to have an exophytic cervical SCNEC. A magnetic resonance image scan showed no evidence of parametrial invasion or distant metastasis. Clinical staging allocated her to stage IB1 disease. She underwent radical abdominal trachelectomy for reproductive purpose. Preoperative and postoperative chemotherapy with ifosfamide/etoposide/cisplatin combining gonadotropin-releasing hormone agonist were administered. She had a spontaneous, uneventful pregnancy and successfully delivered a term baby via cesarean section 7 years after treatment.ConclusionTo our knowledge, we describe the first success in offering a fertility-preserving multimodality strategy to present favorable oncologic, reproductive, and obstetric outcomes in a fertile woman of stage I SCNEC. Individualized multimodality therapy may be utilized in specific patients with early-stage cervical cancer to preserve their fertility.

【 授权许可】

CC BY   
© The Author(s). 2017