AB0 blood group and prognosis in patients with pancreatic cancer

BMC Cancer

Research Article

Ulf Hinz¹  Ulrich Bork¹  Johanna Kirchberg¹  Moritz Koch¹  Nuh N Rahbari¹  Markus W Büchler¹  Jürgen Weitz¹  Albrecht Leo² 

[1] Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld, 110 69120, Heidelberg, Germany;Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, University of Heidelberg, Heidelberg, Germany;

关键词: Pancreatic Cancer;    Blood Group;    Pancreatic Ductal Adenocarcinoma;    Pancreatic Cancer Patient;    Blood Group Antigen;   

DOI  :  10.1186/1471-2407-12-319

 received in 2012-02-25, accepted in 2012-07-19,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundAlthough blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer.MethodsA total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses.ResultsIn patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 – 0.99; p = 0.037).ConclusionAB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.

【 授权许可】

CC BY   
© Rahbari et al.; licensee BioMed Central Ltd. 2012