Long chain n-3 polyunsaturated fatty acids and vascular function in patients with chronic kidney disease and healthy subjects: a cross-sectional and comparative study

BMC Nephrology

Research Article

Christian Aalkjær¹  Morten Borg²  Erik B. Schmidt³  Jeppe H. Christensen⁴  Per Ivarsen⁵  Johan V. Povlsen⁵  My Svensson⁶ 

[1] Department of Biomedicine, Aarhus University, Aarhus, Denmark;Department of Biomedicine, Aarhus University, Aarhus, Denmark;Department of Respiratory Medicine and Allergology, Aarhus University Hospital, Nørrebrogade 44, build. 2A, 8000, Aarhus C, Denmark;Department of Internal Medicine, Horsens Regional Hospital, Horsens, Denmark;Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark;Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark;Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark;Department of Nephrology, Akershus University Hospital, Lørenskog, Norway;

关键词: Polyunsaturated fatty acids;    Hemodynamic;    Resistance artery;    Chronic kidney disease;   

DOI  :  10.1186/s12882-016-0393-5

 received in 2015-08-24, accepted in 2016-11-09,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPatients with chronic kidney disease have a markedly increased cardiovascular mortality compared with the general population. Long chain n-3 polyunsaturated fatty acids have been suggested to possess cardioprotective properties. This cross-sectional and comparative study evaluated correlations between hemodynamic measurements, resistance artery function and fish consumption to the content of long chain n-3 polyunsaturated fatty acids in adipose tissue, a long-term marker of seafood intake.MethodsSeventeen patients with chronic kidney disease stage 5 + 5d and 27 healthy kidney donors were evaluated with hemodynamic measurements before surgery; from these subjects, 11 patients and 11 healthy subjects had vasodilator properties of subcutaneous resistance arteries examined. The measurements were correlated to adipose tissue n-3 polyunsaturated fatty acids. Information on fish intake was obtained from a dietary questionnaire and compared with adipose tissue n-3 polyunsaturated fatty acids.ResultsFish intake and the content of n-3 polyunsaturated fatty acids in adipose tissue did not differ between patients and controls. n-3 polyunsaturated fatty acid levels in adipose tissue were positively correlated to systemic vascular resistance index; (r = 0.44; p = 0.07 and r = 0.62; p < 0.05, chronic kidney disease and healthy subjects respectively) and negatively correlated to cardiac output index (r = −0.69; p < 0.01 and r = −0.50; p < 0.05, chronic kidney disease and healthy subjects respectively). No correlation was observed between n-3 polyunsaturated fatty acid levels in adipose tissue and vasodilator properties in resistance arteries. n-3 PUFA content in adipose tissue increased with increasing self-reported fish intake.ConclusionsThe correlations found, suggest a role for n-3 polyunsaturated fatty acids in hemodynamic properties. However, this is apparently not due to changes in intrinsic properties of the resistance arteries as no correlation was found to n-3 polyunsaturated fatty acids.

【 授权许可】

CC BY   
© The Author(s). 2016