Cytomegalovirus, Epstein-Barr virus and varicella zoster virus infection in the first two years of life: a cohort study in Bradford, UK

BMC Infectious Diseases

Research Article

Dagmar Waiblinger¹  John Wright¹  Paul Griffiths²  Rafaq Azad³  Lucy Pembrey⁴  Mauli Patel⁵ 

[1] Bradford Institute for Health Research, Bradford, UK;Centre for Virology, University College London Medical School, London, UK;Department of Biochemistry, Bradford Royal Infirmary, Bradford, UK;Department of Medical Statistics, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Virology Department, Royal Free Hospital, London, UK;

关键词: Cytomegalovirus;    Epstein Barr virus;    Varicella zoster virus;    Children;    Ethnic group;    UK;   

DOI  :  10.1186/s12879-017-2319-7

 received in 2016-12-07, accepted in 2017-03-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group.MethodsChildren enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age. Ordered logistic regression quantified associations between ethnicity and other risk factors and age at CMV/EBV/VZV infection (<12 months, 12–24 months, uninfected at 24 months).ResultsPakistani children (n = 472) were more likely to be infected with CMV and EBV at a younger age than White British children (n = 391) (CMV: adjusted odds ratio (OR) 2.53, 95% confidence interval (CI) 1.47–4.33; EBV: adjusted OR 2.16, 95% CI 1.43–3.26). Conversely, Pakistani children had lower odds of being VZV infected in the second year than White British children (adjusted OR 0.57, 95% CI 0.33–0.97). There was a strong association between increasing birth order and later CMV infection in Pakistani children.ConclusionsWe report large differences in CMV and EBV incidence in the first 2 years between Pakistani and White British children born in Bradford, which cannot be explained by differences in risk factors for infection. Our data will inform the optimum schedule for future CMV and EBV vaccination programmes.

【 授权许可】

CC BY   
© The Author(s). 2017