Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

BMC Cancer

Research Article

Paul A. Demers¹  Linda Kachuri¹  M. Anne Harris²  Paul A. Peters³  Michael Tjepkema⁴  Jill S. MacLeod⁵ 

[1] Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th Floor, M5T 3M7, Toronto, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, 3rd Floor, M5G 2L3, Toronto, ON, Canada;Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, M5G 2L7, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th Floor, M5T 3M7, Toronto, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, 3rd Floor, M5G 2L3, Toronto, ON, Canada;School of Occupational and Public Health, Ryerson University, 350 Victoria Street, POD 249, M5B 2K3, Toronto, ON, Canada;Departments of Sociology and Economics, University of New Brunswick, Tilley Hall 015, 9 Macaulay Lane, E3B 5A3, Fredericton, NB, Canada;Health Analysis Division, Statistics Canada, 150 Tunney’s Pasture Driveway, K1A 0T6, Ottawa, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, 3rd Floor, M5G 2L3, Toronto, ON, Canada;Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, M5G 2L7, Toronto, ON, Canada;

关键词: Cancer Risk;    Thyroid Cancer;    Livestock Farmer;    Agricultural Worker;    Crop Farmer;   

DOI  :  10.1186/s12885-017-3346-x

 received in 2016-06-26, accepted in 2017-05-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAgricultural workers may be exposed to potential carcinogens including pesticides, sensitizing agents and solar radiation. Previous studies indicate increased risks of hematopoietic cancers and decreased risks at other sites, possibly due to differences in lifestyle or risk behaviours. We present findings from CanCHEC (Canadian Census Health and Environment Cohort), the largest national population-based cohort of agricultural workers.MethodsStatistics Canada created the cohort using deterministic and probabilistic linkage of the 1991 Canadian Long Form Census to National Cancer Registry records for 1992–2010. Self-reported occupations were coded using the Standard Occupational Classification (1991) system. Analyses were restricted to employed persons aged 25–74 years at baseline (N = 2,051,315), with follow-up until December 31, 2010. Hazard ratios (HR) and 95% confidence intervals (CI) were modeled using Cox proportional hazards for all workers in agricultural occupations (n = 70,570; 70.8% male), stratified by sex, and adjusted for age at cohort entry, province of residence, and highest level of education.ResultsA total of 9515 incident cancer cases (7295 in males) occurred in agricultural workers. Among men, increased risks were observed for non-Hodgkin lymphoma (HR = 1.10, 95% CI = 1.00–1.21), prostate (HR = 1.11, 95% CI = 1.06–1.16), melanoma (HR = 1.15, 95% CI = 1.02–1.31), and lip cancer (HR = 2.14, 95% CI = 1.70–2.70). Decreased risks in males were observed for lung, larynx, and liver cancers. Among female agricultural workers there was an increased risk of pancreatic cancer (HR = 1.36, 95% CI = 1.07–1.72). Increased risks of melanoma (HR = 1.79, 95% CI = 1.17–2.73), leukemia (HR = 2.01, 95% CI = 1.24–3.25) and multiple myeloma (HR = 2.25, 95% CI = 1.16–4.37) were observed in a subset of female crop farmers.ConclusionsExposure to pesticides may have contributed to increased risks of hematopoietic cancers, while increased risks of lip cancer and melanoma may be attributed to sun exposure. The array of decreased risks suggests reduced smoking and alcohol consumption in this occupational group compared to the general population.

【 授权许可】

CC BY   
© The Author(s). 2017