Case report: severe cytomegalovirus primary infection in an immunocompetent adult with disseminated intravascular coagulation treated with valganciclovir

BMC Infectious Diseases

Case Report

Niklas F. Müller¹  Nisar P. Malek¹  Christoph P. Berg¹  Klaus Hamprecht²  Matthias Schampera²  Gerhard Jahn² 

[1] Department of Internal Medicine I, University Hospital of Tuebingen, D-72076 Tuebingen, Germany;Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tuebingen, D-72076 Tuebingen, Germany;

关键词: CMV primary infection;    Valganciclovir;    DIC;    Neutralisation;    Avidity maturation;   

DOI  :  10.1186/s12879-016-1343-3

 received in 2015-07-03, accepted in 2016-01-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundDisseminated intravascular coagulation (DIC) is a very rare complication of disseminated cytomegalovirus (CMV) infection. So far it is mainly described for immunocompromised patients.Case presentationA 49-year-old immunocompetent Caucasian male presented with sudden onset of fever and DIC due to primary CMV infection, which was treated with Valganciclovir. CMV-specific IgG-avidity and epithelial cell-specific neutralisation-capacity developed five weeks after onset of symptoms. We describe the first case of an immunocompetent patient suffering from DIC due to a CMV primary infection successfully treated with Valganciclovir.ConclusionsPrimary CMV infection can occur accompanied with life threatening complications even in immunocompetent patients. Immediate treatment with Valganciclovir should be considered as an early treatment of choice in severe cases since specific neutralisation capacity might need several weeks to develop.

【 授权许可】

CC BY   
© Müller et al. 2016