Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

BMC Cardiovascular Disorders

Research Article

Maria Rosvall¹  Gerd Östling¹  Peter Almgren¹  Gunnar Engström¹  Margaretha Persson²  Bo Hedblad²  Olle Melander²  Erik Hallengren³  Joachim Struck⁴  Andreas Bergmann⁵ 

[1] Department of Clinical Sciences, Lund University, Malmö, Sweden;Department of Clinical Sciences, Lund University, Malmö, Sweden;Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden;Department of Clinical Sciences, Lund University, Malmö, Sweden;Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden;Department of Internal Medicine, SUS, Skåne University Hospital, Inga Marie Nilssons gata 36, SE 205 02, Malmö, Sweden;SphingoTec GmbH, Hohen Neuendorf, Germany;SphingoTec GmbH, Hohen Neuendorf, Germany;Waltraut Bergmann Foundation, Hohen Neuendorf, Germany;

关键词: Growth hormone;    Statins;    Imt;    Lipids;    Cardiovascular disease;   

DOI  :  10.1186/s12872-017-0563-9

 received in 2017-02-28, accepted in 2017-05-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGrowth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin affects the fasting level of GH.MethodsWe examined the association between GH and IMT in 4425 individuals (aged 46–68 years) included in the baseline examination (1991–1994) of the Malmö Diet and Cancer cardiovascular cohort (MDC-CC). From that cohort we then studied 472 individuals (aged 50-70 years) who also participated (1994–1999) in the β-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS), a randomized, double blind, placebo-controlled, single-center clinical trial. Using multivariate linear regression models we related the change in GH-levels at 12 months compared with baseline to treatment with 40 mg fluvastatin once daily.ResultsIn MDC-CC fasting values of GH exhibited a positive cross-sectional relation to the IMT at the carotid bulb independent of traditional cardiovascular risk factors (p = 0.002). In a gender-stratified analysis the correlation were significant for males (p = 0.005), but not for females (p = 0.09). Treatment with fluvastatin was associated with a minor reduction in the fasting levels of hs-GH in males (p = 0.05) and a minor rise in the same levels among females (p = 0.05).ConclusionsWe here demonstrate that higher fasting levels of GH are associated with thicker IMT in the carotid bulb in males. Treatment with fluvastatin for 12 months only had a minor, and probably not clinically relevant, effect on the fasting levels of hs-GH.

【 授权许可】

CC BY   
© The Author(s). 2017