Racial differences in six major subtypes of melanoma: descriptive epidemiology

BMC Cancer

Research Article

Yinjun Zhao¹  Yu Wang²  Shuangge Ma³ 

[1] School of Public Health, Yale University, 60 College ST, LEPH 206, 06520, New Haven, CT, USA;School of Statistics and The center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave., 100872, Beijing, China;School of Statistics and The center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave., 100872, Beijing, China;School of Public Health, Yale University, 60 College ST, LEPH 206, 06520, New Haven, CT, USA;VA Cooperative Studies Program Coordinating Center, West Haven, CT, USA;

关键词: Melanoma;    Racial difference;    Subtype;    SEER;   

DOI  :  10.1186/s12885-016-2747-6

 received in 2016-01-18, accepted in 2016-08-24,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMelanoma accounts for the majority of skin cancer deaths. It has over thirty different subtypes. Different races have been observed to differ in multiple aspects of melanoma.MethodsSEER (Surveillance, Epidemiology, and End Results) data on six major subtypes, namely melanoma in situ (MIS), superficial spreading melanoma (SSM), nodular melanoma (NM), lentigo maligna melanoma (LMM), acral lentiginous melanoma malignant (ALM), and malignant melanoma NOS (NOS), were analyzed. The racial groups studied included NHW (non-Hispanic white), HW (Hispanic white), Black, and Asian/PI (Pacific Islanders). Univariate and multivariate analysis was conducted to quantify racial differences in patients’ characteristics, incidence, treatment, and survival.ResultsSignificant racial differences are observed in patients’ characteristics. For all subtypes except for ALM, NHWs have the highest incidence rates, followed by HWs, while Blacks have the lowest. For ALM, HWs have the highest rate, followed by NHWs. In stratified analysis, interaction between gender and race is observed. For the first five subtypes and localized and regional NOS, the dominating majority of patients had surgery, while for distant NOS, the distribution of treatment is more scattered. Significant racial differences are observed for distant ALM and NOS. For MIS, SSM, NM, LMM, and ALM, there is no significant racial difference in survival. For NOS, significant racial differences in survival are observed for the localized and regional stages, with NHWs having the best and Blacks having the worst five-year survival rates.ConclusionsRacial differences exist for the six major melanoma subtypes in the U.S. More data collection and analysis are needed to fully describe and interpret the differences across racial groups and across subtypes.

【 授权许可】

CC BY   
© The Author(s). 2016