A potential anatomic subtype of short bowel syndrome: a matched case-control study

BMC Gastroenterology

Research Article

Huicheng Jin¹  Wencheng Kong¹  Rongchao Ying¹  Mingxiao Guo²  Danhua Yao³  Qi Mao³  Jian Wang³  Yousheng Li⁴ 

[1] Department of Gastroenterological Surgery, Hangzhou First People’s Hospital, School of Clinical Medicine, Nanjing Medical University, 310006, Hangzhou, China;Department of Gastroenterological Surgery, Linyi People’s Hospital, 276000, Shandong, China;Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, 210002, Nanjing, China;Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, 210002, Nanjing, China;Department of Surgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, 210002, Nanjing, China;

关键词: Short bowel syndrome;    PN weaning;    Ileum;    Bristol stool scale;    Anatomic subtype;   

DOI  :  10.1186/s12876-016-0425-4

 received in 2015-10-22, accepted in 2016-01-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundFundamental researches suggest that ileum presents greater adaptive potential than the jejunum. However, few studies estimate the association between ileum and adaptive potential in human. To discover the association, we conducted this matched case-control study.MethodsA 1:2 pair-matched, case-control study was conducted from January 1, 2001 to January 1, 2015 in Intestinal Rehabilition and Transplant Center. The case group was ileum predominated (IP) group and the control group was jejunum predominated (JP) group. Demographic data, medical history and progression of each patient were collected.ResultsThere were 24 IP cases and 48 JP controls in this study. The cumulative probabilities of parenteral nutrition (PN) weaning in IP group were higher than that in JP group. The Bristol stool scale scores of IP group were lower than that of JP group at third month. The Cox proportional hazards regression model confirmed that IP had a higher odds of PN weaning (OR = 2.69; 95 % CI: 1.27, 5.70, p = 0.01) as compared with JP group. The conditional logistic regression with 1:2 matching also confirmed IP group had a higher odds (OR = 4.84; 95 % CI: 2.02, 11.56, p <0.01).ConclusionsOur results indicated that ileum presents greater adaptive potential than the jejunum in nutrition and fluid absorption. And a potential anatomic subtype of short bowel syndrome was proposed. Further research need to be conducted to more fully understand the adaptive potential of ileum besides nutrition and fluid absorption.

【 授权许可】

CC BY   
© Kong et al. 2016