The Nakuru eye disease cohort study: methodology & rationale

BMC Ophthalmology

Study Protocol

Andrew Bastawrous¹  Allen Foster¹  Hannah Kuper²  Matthew Burton³  Hillary Rono⁴  Helen A Weiss⁵  Tunde Peto⁶  Wanjiku Mathenge⁷ 

[1] International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, WC1E 7HT, London, UK;International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, WC1E 7HT, London, UK;International Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, WC1E 7HT, London, UK;International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, WC1E 7HT, London, UK;NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, EV1V 2PD, London, UK;Kitale and Zonal eye surgeon, North Rift, Kenya;MRC Tropical Epidemiology Group, Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, WC1E 7HT, London, UK;NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, EV1V 2PD, London, UK;Rwanda International Institute of Ophthalmology, P.O. Box 312, Kigali, Rwanda;The Fred Hollows Foundation, P.O. Box 8683, 00200, Nairobi, Kenya;

关键词: Cohort study;    Longitudinal;    Eye disease;    Africa;    Kenya;    Cataract;    Glaucoma;    Age related macular degeneration;    Diabetic retinopathy;    Refractive error;    Incidence;    Progression;   

DOI  :  10.1186/1471-2415-14-60

 received in 2014-03-07, accepted in 2014-04-03,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundNo longitudinal data from population-based studies of eye disease in sub-Saharan-Africa are available. A population-based survey was undertaken in 2007/08 to estimate the prevalence and determinants of blindness and low vision in Nakuru district, Kenya. This survey formed the baseline to a six-year prospective cohort study to estimate the incidence and progression of eye disease in this population.Methods/DesignA nationally representative sample of persons aged 50 years and above were selected between January 2007 and November 2008 through probability proportionate to size sampling of clusters, with sampling of individuals within clusters through compact segment sampling. Selected participants underwent detailed ophthalmic examinations which included: visual acuity, autorefraction, visual fields, slit lamp assessment of the anterior and posterior segments, lens grading and fundus photography. In addition, anthropometric measures were taken and risk factors were assessed through structured interviews. Six years later (2013/2014) all subjects were invited for follow-up assessment, repeating the baseline examination methodology.DiscussionThe methodology will provide estimates of the progression of eye diseases and incidence of blindness, visual impairment, and eye diseases in an adult Kenyan population.

【 授权许可】

CC BY   
© Bastawrous et al.; licensee BioMed Central Ltd. 2014