HPV.edu study protocol: a cluster randomised controlled evaluation of education, decisional support and logistical strategies in school-based human papillomavirus (HPV) vaccination of adolescents

BMC Public Health

Study Protocol

Spring Cooper¹  Patti Whyte²  Julia M. L. Brotherton³  Cristyn Davies⁴  S. Rachel Skinner⁴  Gregory Zimet⁵  Annette Braunack-Mayer⁶  Julie Leask⁷  Kevin McGeechan⁷  Kirsten McCaffrey⁷  John Kaldor⁸  David G. Regan⁸  Tanya Stoney⁹  Heidi Hutton⁹  Jane Jones⁹  Peter Richmond^1,10  Joanne Collins^1,11  Helen Marshall^1,11  Adriana Parrella^1,11  Melissa Kang^1,12  Suzanne M. Garland^1,13 

[1] CUNY School of Public Health, City University New York, New York City, NY, Australia;Deakin University, SRC Population Health, Deakin Health Economics, Melbourne, VIC, Australia;National HPV Vaccination Program Register, VCS, and School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia;Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Locked Bag 4001, Westmead, 2054, Sydney, NSW, Australia;Pediatrics & Clinical Psychology, Indiana University, Indianapolis, IN, Australia;School of Population Health, University of Adelaide, Adelaide, SA, Australia;School of Public Health, University of Sydney, Sydney, NSW, Australia;The Kirby Institute, Faculty of Medicine, UNSW Australia, Sydney, NSW, Australia;Vaccine Trials Group, Telethon Kids Institute, Perth, WA, Australia;Vaccine Trials Group, Telethon Kids Institute, Perth, WA, Australia;School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia;Vaccinology & Immunology Research Trials Unit, Women’s & Children’s Hospital, Adelaide, South Australia, Australia;Westmead Clinical School, University of Sydney, Sydney, NSW, Australia;Women’s Centre for Infectious Diseases, The Royal Women’s Hospital, Melbourne, VIC, Australia;

关键词: Western Australia;    School Personnel;    Logistical Strategy;    South Australia;    Vaccination Uptake;   

DOI  :  10.1186/s12889-015-2168-5

 received in 2015-07-27, accepted in 2015-08-18,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe National Human Papillomavirus (HPV) Vaccination Program in Australia commenced in 2007 for females and in 2013 for males, using the quadrivalent HPV vaccine (HPV 6,11,16,18). Thus far, we have demonstrated very substantial reductions in genital warts and in the prevalence of HPV among young Australian women, providing early evidence for the success of this public health initiative. Australia has a long history of school-based vaccination programs for adolescents, with comparatively high coverage. However, it is not clear what factors promote success in a school vaccination program. The HPV.edu study aims to examine: 1) student knowledge about HPV vaccination; 2) psycho-social outcomes and 3) vaccination uptake.Methods/DesignHPV.edu is a cluster randomised trial of a complex intervention in schools aiming to recruit 40 schools with year-8 enrolments above 100 students (approximately 4400 students). The schools will be stratified by Government, Catholic, and Independent sectors and geographical location, with up to 20 schools recruited in each of two states, Western Australia (WA) and South Australia (SA), and randomly allocated to intervention or control (usual practice). Intervention schools will receive the complex intervention which includes an adolescent intervention (education and distraction); a decisional support tool for parents and adolescents and logistical strategies (consent form returns strategies, in-school mop-up vaccination and vaccination-day guidelines). Careful process evaluation including an embedded qualitative evaluation will be undertaken to explore in depth possible mechanisms for any observed effect of the intervention on primary and secondary outcomes.DiscussionThis study is the first to evaluate the relative effectiveness of various strategies to promote best practice in school-based vaccination against HPV. The study aims to improve vaccination-related psychosocial outcomes, including adolescent knowledge and attitudes, decision-making involvement, self-efficacy, and to reduce fear and anxiety. The study also aims to improve school vaccination program logistics including reduction in time spent vaccinating adolescents and increased number of consent forms returned (regardless of decision). Less anxiety in adolescents will likely promote more efficient vaccination, which will be more acceptable to teachers, nurses and parents. Through these interventions, it is hoped that vaccination uptake will be increased.Trial registrationAustralian and New Zealand Clinical Trials Registry, ACTRN12614000404628, 14.04.2014.

【 授权许可】

CC BY   
© Skinner et al. 2015