Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study

BMC Cardiovascular Disorders

Research Article

Siegfried Wassertheurer¹  Bernhard Hametner¹  Stephanie Parragh¹  Achim Schwarz²  Matthias Hillebrand³  Ghazaleh Nouri³  Yskert von Kodolitsch³  Jelena Köster⁴  Kai Mortensen⁴ 

[1] AIT Austrian Institute of Technology, Donau-City Str. 1, 1220, Vienna, Austria;IEM GmbH, Cockerillstr. 69, 52222, Stolberg, Germany;Universitäres Herzzentrum Hamburg, Universitätskrankenhaus Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany;Universitätsklinikum Schleswig-Holstein, Medizinische Klinik II, Ratzeburger Allee 160, 23538, Lübeck, Germany;

关键词: Pulse Wave Velocity;    Marfan Syndrome;    Augmentation Index;    Pulse Wave Analysis;    Marfan Patient;   

DOI  :  10.1186/s12872-016-0263-x

 received in 2015-11-25, accepted in 2016-04-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aim of this work is the investigation of measures of ambulatory brachial and aortic blood pressure and indices of arterial stiffness and aortic wave reflection in Marfan patients.MethodsA case-control study was conducted including patients with diagnosed Marfan syndrome following Ghent2 nosology and healthy controls matched for sex, age and daytime brachial systolic blood pressure. For each subject a 24 h ambulatory blood pressure and 24 h pulse wave analysis measurement was performed.ResultsAll parameters showed a circadian pattern whereby pressure dipping was more pronounced in Marfan patients. During daytime only Marfan patients with aortic root surgery showed increased pulse wave velocity. In contrast, various nighttime measurements, wave reflection determinants and circadian patterns showed a significant difference.ConclusionsThe findings of our study provide evidence that ambulatory measurement of arterial stiffness parameters is feasible and that these determinants are significantly different in Marfan syndrome patients compared to controls in particular at nighttime. Further investigation is therefore indicated.

【 授权许可】

CC BY   
© Hillebrand et al. 2016