Bordetella bronchiseptica pneumonia in a patient with lung cancer; a case report of a rare infection

BMC Infectious Diseases

Case Report

Francesco Allegrini¹  Giulia Marcantognini²  Paola Cravero²  Giovanni Luca Frassineti²  Manlio Monti²  Angelo Delmonte²  Valentina Fausti²  Danila Diano³ 

[1] Department of Infectious Diseases, Morgagni-Pierantoni Hospital, Forlì, Italy;Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy;Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy;

关键词: Bordetella bronchiseptica;    Cavitary lung lesion;    Rare infection;    Nivolumab;    Nosocomial infection;   

DOI  :  10.1186/s12879-017-2736-7

 received in 2017-03-06, accepted in 2017-09-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case of B. bronchiseptica pneumonia in a patient with lung cancer.Case presentationA 52-year-old white male with non small cell lung cancer developed fever during treatment with nivolumab. A persistent productive cough and a deterioration in his clinical condition led to his hospitalization for evaluation. Bronchoscopy was performed and a diagnosis of B. bronchiseptica pneumonia was made. The infection was successfully managed by antiobiotic therapy.ConclusionsB. bronchiseptica is a pathogen that can cause serious infection in humans, especially in immunocompromised or immunoincompetent individuals. In our patient it showed unusual resistance to cephalosporins and poor sensitivity to amikacin. To our knowledge this is the first case of such an infection in a lung cancer patient undergoing treatment with nivolumab. When B. bronchiseptica is identified, the possibility of a nosocomial transmission must be considered.

【 授权许可】

CC BY   
© The Author(s). 2017