Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa

BMC Hematology

Research Article

Ifeyinwa Osunkwo¹  Titilola S Akingbola²  Babatunde L Salako³  Bamidele O Tayo⁴  Amy Luke⁴  Ramon Durazo-Arvizu⁴  Richard S Cooper⁴  Jennifer Layden⁵  Jacob Plange-Rhule⁶  Colin A McKenzie⁷  Marvin Reid⁷ 

[1] Aflac Center for Cancer and Blood Disorders Service Comprehensive Sickle Cell Program of Children’s Healthcare of Atlanta, Atlanta, GA, USA;Department of Hematology, College of Medicine, University of Ibadan, Ibadan, Nigeria;Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria;Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, 2160 S. First Ave, 60153, Maywood, IL, USA;Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, 2160 S. First Ave, 60153, Maywood, IL, USA;Department of Medicine, Section of Infectious Diseases, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA;Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;Sickle Cell Unit, Tropical Medicine Research Institute, The University of the West Indies, Kingston, Jamaica;

关键词: Sickle cell disease;    Sickle cell anemia;    Vitamin D;    25-hydroxyvitamin D;    Adult patients;    Tropical Africa;    Jamaica;    West Africa;   

DOI  :  10.1186/2052-1839-14-12

 received in 2013-11-12, accepted in 2014-08-12,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPatients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D (25(OH)D) – compared to controls. Average serum 25(OH)D levels are also substantially lower in African Americans than whites, while population distributions of 25(OH)D among Jamaicans of African descent and West Africans are the same as among USA whites. The purpose of this study was to examine whether adult patients with sickle cell disease living in tropical regions had reduced 25(OH)D relative to the general population.MethodsWe analyzed serum 25(OH)D in stored samples collected from studies in Jamaica and West Africa of adult patients with sickle cell disease and adult population controls.ResultsIn samples of 20 Jamaicans and 50 West Africans with sickle cell disease mean values of 25(OH)D were 37% and 39% lower than controls, respectively. Metabolic abnormalities in the absorption and conversion pathways are possible causes for the consistent relative deficiency of 25(OH)D in sickle cell disease.ConclusionsLow 25(OH)D levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation.

【 授权许可】

CC BY   
© Tayo et al.; licensee BioMed Central Ltd. 2014