Sodium hyaluronate and chondroitin sulfate replenishment therapy can improve nocturia in men with post-radiation cystitis: results of a prospective pilot study

BMC Urology

Research Article

Eleonora Monteleone Pasquetti¹  Lorenzo Livi¹  Beatrice Detti¹  Tatiana Masoni¹  Matthias Oelke²  Enrico Finazzi Agro³  Stavros Gravas⁴  Andrea Minervini⁵  Marco Carini⁵  Vincenzo Li Marzi⁵  Sergio Serni⁵  Omar Saleh⁵  Mauro Gacci⁵  Claudia Giannessi⁵ 

[1] Department of Radiation Therapy, University of Florence, Careggi Hospital, Largo Brambilla 3, Florence, Italy;Department of Urology, Hannover Medical School, Hannover, Germany;Department of Urology, Tor Vergata University, Via di Tor Vergata, Rome, Italy;Department of Urology, University Hospital of Larissa, Larissa, Greece;Department of Urology, University of Florence, Careggi Hospital, Largo Brambilla 3, Urologic Clinic San Luca, 50100, Florence, Italy;

关键词: Prostate cancer;    Acute radiation syndrome;    Cystitis;    Nocturia;    Hyaluronic acid;    Chondroitin sulfate;   

DOI  :  10.1186/s12894-015-0046-1

 received in 2014-08-14, accepted in 2015-06-02,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRadiotherapy is one of the treatment options for prostate cancer (PCa) but up to 25 % of men report about severe nocturia (nocturnal voiding). The combination of hyaluronic acid (HA) and chondroitin sulfate (CS) resembles glycosaminoglycan (GAG) replenishment therapy. The aim of our study was to evaluate the impact of HA and CS on nocturia, in men with nocturia after PCa radiotherapy.MethodsTwenty-three consecutive patients with symptomatic cystitis after external radiotherapy for PCa were enrolled. Patients underwent bladder instillation therapy with HA and CS weekly for the first month and, afterwards, on week 6, 8 and 12. Nocturnal voiding frequency was assessed by item 3 (Q3) of the Interstitial Cystitis Symptoms Index (ICSI) and item 2 (Q2) of the Interstitial Cystitis Problem Index (ICPI). Data were analyzed with paired-samples T-test and adjusted for age.ResultsEighteen patients (78 %) reported about nocturia. Pre- and post-treatment ICSI-Q3 was 2.13 ± 0.28 and 1.61 ± 0.21 (−24.4 %, p = 0.001). With logistic regression analysis, both age and baseline ICSI-Q3 had a significant impact on nocturnal voiding frequency (r = 0.293, p = 0.011 and r = 0.970, p < 0.001). Pre- and post-treatment ICPI-Q2 was 1.87 ± 0.26 and 1.30 ± 0.25 (−30.5 %, p = 0.016); logistic regression analysis was without significant findings.ConclusionBladder instillation treatment with a combination of HA and CS was effective in reducing nocturnal voiding frequency in men with post-radiation bladder pain for PCa. Randomized, controlled trials with sham treatment are needed to confirm our result.

【 授权许可】

CC BY   
© Gacci et al. 2015