Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscle

BMC Complementary and Alternative Medicine

Research Article

Ying Duan¹  Xiangyu Guo²  Wen Sun²  Liansha Huang²  Peifeng Xie²  Lingling Qin²  Jingxin Zhou²  Tunhai Xu³  Tonghua Liu³  Hisae Yoshitomi⁴  Ming Gao⁴ 

[1] Department of Chinese Medicine, Tongren Hospital of Capital Medical University, No.2, Chongwenmennei Street, 100730, Beijing, Dongcheng District, China;Department of Endocrinology, Dongfang Hospital of Beijing University of Chinese Medicine, No.6, 1st Area Fangxing Yuan, 100078, Beijing, Fangzhuang Fengtai District, China;Department of Science and Technology, Beijing University of Chinese Medicine, No.11, North 3rd-ring East Road, 100029, Beijing, Chao Yang District, China;School of Pharmaceutical Sciences of Mukogawa Women’s University, 11-68 Koshien-Kyuban-cho, 663-8179, Nishinomiya, Hyogo, Japan;

关键词: Skeletal Muscle;    Insulin Resistance;    Insulin Sensitivity;    Improve Insulin Sensitivity;    GLUT4 Translocation;   

DOI  :  10.1186/1472-6882-13-52

 received in 2012-08-28, accepted in 2013-02-25,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) have been associated with insulin-resistance; however, the effective therapies in improving insulin sensitivity are limited. This study is aimed at investigating the effect of Guava Leaf (GL) extracts on glucose tolerance and insulin resistance in SHRSP.Z-Leprfa/Izm rats (SHRSP/ZF), a model of spontaneously metabolic syndrome.MethodsMale rats at 7 weeks of age were administered with vehicle water or treated by gavage with 2 g/kg GL extracts daily for six weeks, and their body weights, water and food consumption, glucose tolerance, and insulin resistance were measured.ResultsCompared with the controls, treatment with GL extracts did not modulate the amounts of water and food consumption, but significantly reduced the body weights at six weeks post treatment. Treatment with GL extracts did not alter the levels of fasting plasma glucose and insulin, but significantly reduced the levels of plasma glucose at 60 and 120 min post glucose challenge, also reduced the values of AUC and quantitative insulin sensitivity check index (QUICKI) at 42 days post treatment. Furthermore, treatment with GL extracts promoted IRS-1, AKT, PI3Kp85 expression, then IRS-1, AMKP, and AKT308, but not AKT473, phosphorylation, accompanied by increasing the ratios of membrane to total Glut 4 expression and adiponectin receptor 1 transcription in the skeletal muscles.ConclusionsThese data indicated that GL extracts improved glucose metabolism and insulin sensitivity in the skeletal muscles of rats by modulating the insulin-related signaling.

【 授权许可】

Unknown   
© Guo et al; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.