The 4q27 locus and prostate cancer risk

BMC Cancer

Research Article

Hoa N Hoang¹  Dallas R English²  Gianluca Severi²  Graham G Giles²  Elizabeth A Tindall³  Vanessa M Hayes³  John L Hopper⁴  Melissa C Southey⁵ 

[1] Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, Vic, Australia;Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, Vic, Australia;Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Vic, Australia;Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Sydney Children's Hospital, High St, Randwick, NSW, Australia;Faculty of Medicine, University of New South Wales, Randwick, NSW, Australia;Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Vic, Australia;Department of Pathology, University of Melbourne, Melbourne, Vic, Australia;

关键词: Prostate Cancer;    Prostate Cancer Risk;    4q27 Locus;    Prostate Cancer Development;    Prostate Cancer Susceptibility;   

DOI  :  10.1186/1471-2407-10-69

 received in 2009-11-11, accepted in 2010-02-25,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundChronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes IL-2 and the recently described IL-21.MethodsWe genotyped six variants previously associated with autoimmune disease (namely rs13151961, rs13119723, rs17388568, rs3136534, rs6822844 and rs6840978) and one functional IL-2 promoter variant (rs2069762) for possible association with prostate cancer risk using the Australian Risk Factors for Prostate Cancer case-control Study.ResultsOverall, our results do not support an association between the seven variants at position 4q27 and prostate cancer risk. Per allele odds ratios (ORs) were not significantly different from 1 (all P-values = 0.06). However, we found suggestive evidence for a significant association between the presence of the rs13119723 variant (located in a protein of unknown function) and men with a family history of prostate cancer in first-degree relatives (P-value for interaction 0.02). The per allele OR associated with this variant was significantly higher than 1 (2.37; 95% C.I. = 1.01-5.57).ConclusionsWe suggest that genetic variation within the chromosome 4q27 locus might be associated with prostate cancer susceptibility in men with a family history of the disease. Furthermore, our study alludes to a potential role of unknown protein KIAA1109 in conferring this risk.

【 授权许可】

Unknown   
© Tindall et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.