C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study)

BMC Cardiovascular Disorders

Research Article

Demet Toprak¹  Gerald S Berenson²  Wei Chen²  Ji Hua Xu²  Sathanur Srinivasan²  Ramprasad Kandavar³  Asif Anwar⁴  Ahmet Toprak⁴ 

[1]Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA

[2]Tulane Center for Cardiovascular Health, New Orleans, LA, USA

[3]Tulane University School of Medicine, Department of Internal Medicine, New Orleans, LA, USA

[4]Tulane University School of Medicine, Heart and Vascular Institute, New Orleans, LA, USA

关键词: Carotid artery intima-media thickness progression;    cardiovascular risk;    c-reactive protein;    epidemiology;    young adults;   

DOI  :  10.1186/1471-2261-11-78

 received in 2011-06-02, accepted in 2011-12-30,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundConflicting information exists regarding the association between hsCRP and the progression of early stages of atherosclerosis. The purpose of the study was to investigate the association of high sensitiviy c-reactive protein (hsCRP) along with major cardiovascular (CV) risk factors on early carotid atherosclerosis progression in a large, population-based cohort study.MethodsThe study cohort included 839 young adults (aged 24 to 43 years, 70% white, 42% men) enrolled in Bogalusa Heart Study, who in 2001-2002 attended baseline examination with measurements of CV risk factors. Progression of carotid artery intima-media thickness (IMT) was assessed during a mean follow-up of 2.4 years.ResultsCarotid artery IMT progression rates were as follows: composite carotid artery = 9.2 ± 52 μm/y, common carotid artery = 0.0 ± 51 μm/y, carotid bulb = 8.8 ± 103 μm/y, and internal carotid artery = 18.9 ± 81 μm/y. Elevated baseline hsCRP, reflecting an inflammatory state, showed independent association with composite carotid artery IMT progression. Increased age, systolic blood pressure, fasting glucose, LDL cholesterol, and current smoking were other risk associates of carotid artery IMT progression in young adults, indicating an underlying burden on the CV system by multiple risk factors.ConclusionIn this population-based study, we observed independent categorical association of increased hsCRP with carotid artery IMT progression in young adults. This study underlines the importance of assesssing hsCRP levels along with smoking and traditional CV risk factor profiles in asymptomatic young adults.

【 授权许可】

Unknown   
© Toprak et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.