Using water-soluble C60 fullerenes in anticancer therapy

Cancer Nanotechnology

Original Paper

U. Ritter¹  Ch. Schütze¹  I. I. Grynyuk²  Yu. I. Prylutskyy²  S. V. Prylutska²  A. P. Burlaka³  P. P. Klymenko⁴ 

[1] Department of Chemistry, Technical University of Ilmenau, Weimarer Str. 25, 098693, Ilmenau, Germany;Institute of Biology, Kyiv National Taras Shevchenko University, Volodymyrska Str., 64, 01601, Kyiv, Ukraine;R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Vasylkivska Str. 45, 03022, Kyiv, Ukraine;State Institute of Gerontology of AMS of Ukraine, Vyshgorodska Str., 67, 04114, Kyiv, Ukraine;

关键词: C fullerenes;    Mice line C57Bl/6J;    Lewis lung carcinoma;    Tumor growth inhibition;    Increasing of animal life;    Survival of animals;    Metastasis inhibition index;    Histological data;   

DOI  :  10.1007/s12645-011-0020-x

 received in 2011-07-08, accepted in 2011-08-05,  发布年份 2011

来源: Springer

【 摘 要 】

Growth experiments of transplanted malignant tumors in the presence of water-soluble C60 fullerenes were performed on groups of mice. It was found that C60 fullerenes efficiently inhibit the growth of transplanted malignant tumors. This behavior can be explained through their high antioxidant activity and the blocking of the specific cell receptors (for example, endothelial growth factor). The findings demonstrate the possibility of using C60 fullerenes in anticancer therapy.

【 授权许可】

Unknown   
© Springer-Verlag 2011