The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population

BMC Cardiovascular Disorders

Research Article

Tung-Hsin Wu¹  Fei-Shih Yang²  Chun-Ho Yun³  Cheng-Huang Su⁴  Yau-Huei Lai⁴  Charles Jia-Yin Hou⁴  Kuo-Tzu Sung⁴  Hung-I Yeh⁴  Ta-Chuan Hung⁵  Chung-Lieh Hung⁵  Hiram G. Bezerra⁶ 

[1] Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan;Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Hsinchu, Taiwan;Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan;Mackay Medical College, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Hsinchu, Taiwan;Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan;Mackay Medical College, Taipei, Taiwan;The Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan;University Hospitals Harrington Heart & Vascular Institute, Division of Cardiology, Case Western Reserve University, Cleveland, OH, USA;

关键词: Pericardial fat;    Diastolic dysfunction;    Dyssynchrony;    Tissue Doppler;   

DOI  :  10.1186/s12872-015-0136-8

 received in 2015-06-26, accepted in 2015-10-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundVisceral adipose tissue, a biologically active fat depot, has been proposed as a reliable marker for visceral adiposity and metabolic abnormalities. Effects of such adiposity on LV diastolic function and dyssynchrony remained largely unknown.MethodsWe assessed pericardial fat (PCF) and thoracic peri-aortic fat (TPAF) by three-dimensional (3D) volume-vender multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Echo-derived diastolic parameters and tissue Doppler imaging (TDI) defined mitral annular systolic (S’), early diastolic (E’) velocities as well as LV filling (E/E’) were all obtained. Intra-ventricular systolic (Sys-D) and diastolic (Dias-D) dyssynchrony were assessed by TDI method.ResultsA total of 318 asymptomatic subjects (mean age: 53.5 years, 36.8 % female) were eligible in this study. Greater PCF and TPAF were both associated with unfavorable diastolic indices and higher diastolic dyssynchrony (all p < 0.05). These associations remained relatively unchanged in multi-variate models. PCF and TPAF set at 81.68 & 8.11 ml yielded the largest sensitivity and specificity (78.6 and 60 % for PCF, 75 and 66.6 % for TPAF, respectively) in predicting abnormally high LV diastolic dyssynchrony, which was defined as Dias-D≧55 ms.ConclusionIncreasing visceral adiposity may be associated with adverse effects on myocardium, primarily featured by worse diastolic function and greater degree of dyssynchrony.

【 授权许可】

CC BY   
© Lai et al. 2015