Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

BMC Complementary and Alternative Medicine

Research Article

Chae Ha Yang¹  Suchan Chang¹  Eun Byeol Lee¹  Jong Han Lee¹  Gyu Won Lee¹  Tae Young Yang¹  Eun Young Jang¹  Hee Young Kim²  Jin Suk Koo³  Yeonhee Ryu⁴ 

[1]College of Korean Medicine, Daegu Haany University, 42158, Daegu, South Korea

[2]College of Korean Medicine, Daegu Haany University, 42158, Daegu, South Korea

[3]Department of Physiology, College of Korean Medicine, Daegu Haany University, 42158, Daegu, South Korea

[4]Department of Bioresource Science, Andong National University, 36729, Andong, South Korea

[5]Korean Medicine Fundamental Research Division, Korea Institute of Oriental Medicine, 34054, Daejeon, South Korea

关键词: Acupuncture;    Anxiety;    Dorsal raphe nucleus;    LPS;    Serotonin transporter;   

DOI  :  10.1186/s12906-017-2039-y

 received in 2017-08-30, accepted in 2017-11-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAcupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disorders. The aim of this study was to evaluate the effects of acupuncture on lipopolysaccharide (LPS)-induced anxiety-like behaviors and SERT in the dorsal raphe nuclei (DRN).MethodsRats were given acupuncture at ST41 (Jiexi), LI11 (Quchi) or SI3 (Houxi) acupoint in LPS-treated rats. Anxiety-like behaviors of elevated plus maze (EPM) and open field test (OFT) were measured and expressions of SERT and/or c-Fos were also examined in the DRN using immunohistochemistry.ResultsThe results showed that 1) acupuncture at ST41 acupoint, but neither LI11 nor SI3, significantly attenuated LPS-induced anxiety-like behaviors in EPM and OFT, 2) acupuncture at ST41 decreased SERT expression increased by LPS in the DRN.ConclusionsOur results suggest that acupuncture can ameliorate anxiety-like behaviors, possibly through regulation of SERT in the DRN.

【 授权许可】

CC BY   
© The Author(s). 2017