Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain

BMC Complementary and Alternative Medicine

Research Article

Miguel L. Neto¹  Roberto S. Moura¹  Ângela C. Resende¹  Gisele Zapata-Sudo²  Rachel V. Amaral²  Roberto T. Sudo²  Carlos E.S. Monteiro²  Pergentino J.C. Souza³ 

[1] Department of Pharmacology and Psychobiology, IBRAG, State University of Rio de Janeiro, UERJ, Av. 28 de setembro, 87 fundos 5° andar sala 7, Vila Isabel, 20551-030, Rio de Janeiro, Brazil;Program of Research in Drug Development, Institute of Biomedical Science, Federal University of Rio de Janeiro, UFRJ, Brazil. Av. Carlos Chagas Filho, 373 - Centro de Ciências da Saúde – bloco J, sala 14. Cidade Universitária – Ilha do Fundão, 21941-902, Rio de Janeiro, Brazil;School of Pharmacy, Federal University of Para, Para, Brazil;

关键词: Euterpe oleracea;    Arecaceae;    Hyperalgesia;    Allodynia;    Acute and chronic pain;   

DOI  :  10.1186/s12906-015-0724-2

 received in 2014-11-06, accepted in 2015-06-15,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPlants rich in flavonoids, such as açaí (Euterpe oleraceae Mart.), can induce antinociception in experimental animals. Here, we tested an extract obtained from the stones of açaí fruits (açaí stone extract, ASE), a native plant from the Amazon region of Brazil, in models of acute/inflammatory and chronic pain.MethodsAntinociceptive effects of ASE were evaluated in the hot plate, formalin, acetic acid writhing, carrageenan, and neuropathic pain models, as well as in thermal hyperalgesia and mechanical allodynia models induced by spinal nerve ligation. Antinociceptive activities were modulated by the administration of cholinergic, adrenergic, opioid, and L-arginine-NO antagonists.ResultsOral administration of ASE (30, 100, or 300 mg.kg−1) dose-dependently reduced nociceptive responses to acute/inflammatory pain in mice, including thermal hyperalgesia, acetic acid-induced writhing, and carrageenan-induced thermal hyperalgesia. Moreover, ASE reduced the neurogenic and inflammatory phases after intraplantar injection of formalin in mice. The antinociceptive effect of ASE (100 mg · kg−1) in a hot plate protocol, was inhibited by pre-treatment with naloxone (1 mg · kg−1), atropine (2 mg · kg−1), yohimbine (5 mg · kg−1), or L-NAME (30 mg · kg−1). Furthermore, ASE prevented chronic pain in a rat spinal nerve ligation model, including thermal hyperalgesia and mechanical allodynia.ConclusionASE showed significant antinociceptive effect via a multifactorial mechanism of action, indicating that the extract may be useful in the development of new analgesic drugs.

【 授权许可】

CC BY   
© Sudo et al. 2015