Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study

BMC Public Health

Research Article

Peter Vollenweider¹  Gérard Waeber¹  Vincent Mooser²  Franziska Marti³  Murielle Bochud³  Fred Paccaud³  Pedro-Manuel Marques-Vidal⁴ 

[1] Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;Department of pathology and laboratory medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;University Institute of Social and Preventive Medicine (IUMSP), University of Lausanne and Centre Hospitalier Universitaire Vaudois (CHUV), 1005, Lausanne, Switzerland;University Institute of Social and Preventive Medicine (IUMSP), University of Lausanne and Centre Hospitalier Universitaire Vaudois (CHUV), 1005, Lausanne, Switzerland;CardioMet, University of Lausanne, Switzerland;

关键词: Chronic Kidney Disease;    Uric Acid;    Glomerular Filtration Rate;    Homocysteine;    Chronic Kidney Disease Patient;   

DOI  :  10.1186/1471-2458-11-733

 received in 2011-08-15, accepted in 2011-09-26,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIncreased serum levels of homocysteine and uric acid have each been associated with cardiovascular risk. We analyzed whether homocysteine and uric acid were associated with glomerular filtration rate (GFR) and albuminuria independently of each other. We also investigated the association of MTHFR polymorphisms related to homocysteine with albuminuria to get further insight into causality.MethodsThis was a cross-sectional population-based study in Caucasians (n = 5913). Hyperhomocysteinemia was defined as total serum homocysteine ≥ 15 μmol/L. Albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g.ResultsUric acid was associated positively with homocysteine (r = 0.246 in men and r = 0.287 in women, P < 0.001). The prevalence of albuminuria increased across increasing homocysteine categories (from 6.4% to 17.3% in subjects with normal GFR and from 3.5% to 14.5% in those with reduced GFR, P for trend < 0.005). Hyperhomocysteinemia (OR = 2.22, 95% confidence interval: 1.60-3.08, P < 0.001) and elevated serum uric acid (OR = 1.27, 1.08-1.50, per 100 μmol/L, P = 0.004) were significantly associated with albuminuria, independently of hypertension and type 2 diabetes. The 2-fold higher risk of albuminuria associated with hyperhomocysteinemia was similar to the risk associated with hypertension or diabetes. MTHFR alleles related to higher homocysteine were associated with increased risk of albuminuria.ConclusionsIn the general adult population, elevated serum homocysteine and uric acid were associated with albuminuria independently of each other and of renal function.

【 授权许可】

Unknown   
© Marti et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.