Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report

BMC Complementary and Alternative Medicine

Research Article

Kathleen Meeske¹  Roberta McKean-Cowdin²  Rachel Ballard-Barbash³  Ashley W Smith³  Catherine M Alfano³  Stephanie M George⁴  Huiyan Ma⁵  Leslie Bernstein⁵  Jane Sullivan-Halley⁵  Kathy B Baumgartner⁶  Marian L Neuhouser⁷  Anne McTiernan⁷ 

[1] Childrens Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, 90027, Los Angeles, CA, USA;Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 90089, Los Angeles, CA, USA;Division of Cancer Control and Population Sciences, National Cancer Institute, 20892, Bethesda, MD, USA;Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20892, Bethesda, MD, USA;Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, 91010, City of Hope, Duarte, CA, USA;Epidemiology and Clinical Investigation Sciences, School of Public Health & Information Sciences, University of Louisville, 40202, Louisville, KY, USA;Fred Hutchinson Cancer Research Center, 98109, Seattle, WA, USA;

关键词: Breast Cancer Survivor;    Mental Component Summary Score;    Physical Component Summary Score;    Recreational Physical Activity;    Black Cohosh;   

DOI  :  10.1186/1472-6882-11-109

 received in 2011-04-27, accepted in 2011-11-08,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIt remains unclear whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.MethodsWe examined the associations of EBS use with health-related quality of life (HRQOL), with fatigue, and with 15 hormone-related symptoms such as hot flashes and night sweats among 767 breast cancer survivors participating in the Health, Eating, Activity, and Lifestyle (HEAL) Study. HRQOL was measured by the Medical Outcomes Study short form-36 physical and mental component scale summary score. Fatigue was measured by the Revised-Piper Fatigue Scale score.ResultsNeither overall EBS use nor the number of EBS types used was associated with HRQOL, fatigue, or hormone-related symptoms. However, comparisons of those using each specific type of EBS with non-EBS users revealed the following associations. Soy supplements users were more likely to have a better physical health summary score (odds ratio [OR] = 1.66, 95% confidence interval [CI] = 1.02-2.70). Flaxseed oil users were more likely to have a better mental health summary score (OR = 1.76, 95% CI = 1.05-2.94). Ginseng users were more likely to report severe fatigue and several hormone-related symptoms (all ORs ≥ 1.7 and all 95% CIs exclude 1). Red clover users were less likely to report weight gain, night sweats, and difficulty concentrating (all OR approximately 0.4 and all 95% CIs exclude 1). Alfalfa users were less likely to experience sleep interruption (OR = 0.28, 95% CI = 0.12-0.68). Dehydroepiandrosterone users were less likely to have hot flashes (OR = 0.33, 95% CI = 0.14-0.82).ConclusionsOur findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life, but further verification is necessary.

【 授权许可】

CC BY   
© Ma et al; licensee BioMed Central Ltd. 2011