BMC Gastroenterology | |
A multi-centre randomised double-blind placebo-controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT colonography | |
Research Article | |
Susanne Eberl1  Markus W Hollmann1  Thierry N Boellaard2  Jurgen H Runge2  Marije P van der Paardt2  Lex J Schouten2  Jeroen AW Tielbeek2  Giedre Kavaliauskiene2  Jaap Stoker2  Jan Peringa3  | |
[1] Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, 1100 DD, Amsterdam, The Netherlands;Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands;Department of Radiology, Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands; | |
关键词: Randomised controlled trial; Colonography; Computed tomographic; Alfentanil; Analgesics; Opioid; Patient satisfaction; | |
DOI : 10.1186/1471-230X-13-94 | |
received in 2013-01-30, accepted in 2013-05-21, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
BackgroundPain is common during colonic insufflation required for CT colonography. We therefore evaluate whether a single intravenous alfentanil bolus has a clinically relevant analgesic effect compared with placebo in patients undergoing CT colonography.MethodsA prospective multi-centre randomised double-blind placebo-controlled trial was performed in patients scheduled for elective CT colonography. Patients were randomised to receive either a bolus of 7.5 μg/kg alfentanil (n = 45) or placebo (n = 45). The primary outcome was the difference in maximum pain during colonic insufflation on an 11-point numeric rating scale. We defined a clinically relevant effect as a maximum pain reduction of at least 1.3 points. Secondary outcomes included total pain and burden of CT colonography (5-point scale), the most burdensome aspect and side effects. Our primary outcome was tested using a one-sided independent samples t-test.ResultsMaximum pain scores during insufflation were lower with alfentanil as compared with placebo, 5.3 versus 3.0 (P < 0.001). Total CT colonography pain and burden were also lower with alfentanil (2.0 vs. 1.6; P = 0.014 and 2.1 vs. 1.7; P = 0.007, respectively). With alfentanil fewer patients rated the insufflation as most burdensome aspect (56.1% vs. 18.6%; P = 0.001). Episodes with desaturations < 90% SpO2 were more common with alfentanil (8.1% vs. 44.4%; P < 0.001, but no clinically relevant desaturations occurred.ConclusionsA low-dose intravenous alfentanil bolus provides a clinically relevant reduction of maximum pain during CT colonography and may improve the CT colonography acceptance, especially for patients with a low pain threshold.Trial registrationDutch Trial Register: NTR2902
【 授权许可】
CC BY
© Boellaard et al.; licensee BioMed Central Ltd. 2013
【 预 览 】
Files | Size | Format | View |
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RO202311092502229ZK.pdf | 665KB | download |
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