Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy

BMC Urology

Research Article

Noriyasu Kawai¹  Takahiro Yasui¹  Taku Naiki¹  Kenjiro Kohri¹  Yoshiyuki Kojima¹  Keiichi Tozawa¹  Takehiko Okamura²  Hidetoshi Akita²  Daisuke Nagata³ 

[1] Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, 467-8601, Mizuho-ku, Nagoya, Japan;Department of Urology, Anjo Kosei Hospital, Anjo, Japan;Department of Urology, East Medical Center Higashi Municipal Hospital City of Nagoya, Nagoya, Japan;

关键词: Prostate cancer;    Neoadjuvant hormonal therapy;    Laparoscopic radical prostatectomy;   

DOI  :  10.1186/1471-2490-12-36

 received in 2012-05-08, accepted in 2012-12-10,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundFew reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate the safety and efficacy of NHT prior to LRP for locally confined prostate cancer.MethodsFrom January 2004 to September 2009, 342 patients undergoing LRP were analyzed, specifically comparing 72 patients who received NHT to 270 who did not. All patients were in clinical stage T2 and nerve sparing LRP were not included.ResultsThe mean patient age, preoperative prostate specific antigen (PSA), clinical stage, and biopsy Gleason grade were similar for the NHT and the non-NHT LRP groups. The median blood loss and the median operative time were also similar. There were no differences in the intraoperative complication rate of rectum injury, blood transfusion, and open surgery conversion. The positive surgical margin rate was significantly improved in NHT patients. Moreover, PSA recurrence within two years was significantly less in long-term NHT than in non-NHT patients.ConclusionsLRP was shown as a safe and efficacious procedure in patients who have received NHT. Perioperative morbidity of NHT patients undergoing LRP appears equivalent to non-NHT patients, with lower positive surgical margin, and PSA recurrence rate.

【 授权许可】

Unknown   
© Naiki et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.