Duplicability of self-interacting human genes

BMC Evolutionary Biology

Research Article

Takashi Makino¹  Åsa Pérez-Bercoff¹  Aoife McLysaght¹ 

[1] Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland;

关键词: Gene Ontology;    Gene Duplication;    Duplicate Gene;    Protein Interaction Network;    Whole Genome Duplication;   

DOI  :  10.1186/1471-2148-10-160

 received in 2009-09-14, accepted in 2010-05-28,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model proposes that the evolution of new protein-protein interactions and protein complexes proceeds through the duplication of self-interacting genes. This model is supported by data from yeast. We examined the relationship between gene duplication and self-interaction in the human genome.ResultsWe investigated the patterns of self-interaction and duplication among 34808 interactions encoded by 8881 human genes, and show that self-interacting proteins are encoded by genes with higher duplicability than genes whose proteins lack this type of interaction. We show that this result is robust against the system used to define duplicate genes. Finally we compared the presence of self-interactions amongst proteins whose genes have duplicated either through whole-genome duplication (WGD) or small-scale duplication (SSD), and show that the former tend to have more interactions in general. After controlling for age differences between the two sets of duplicates this result can be explained by the time since the gene duplication.ConclusionsGenes encoding self-interacting proteins tend to have higher duplicability than proteins lacking self-interactions. Moreover these duplicate genes have more often arisen through whole-genome rather than small-scale duplication. Finally, self-interacting WGD genes tend to have more interaction partners in general in the PIN, which can be explained by their overall greater age. This work adds to our growing knowledge of the importance of contextual factors in gene duplicability.

【 授权许可】

Unknown   
© Pérez-Bercoff et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.