Does obesity have detrimental effects on IVF treatment outcomes?

BMC Women's Health

Research Article

Safak Olgan¹  Mehmet Sakinci¹  Munire Erman Akar¹  Murat Ozekinci¹  Seyit Temel Ceyhan²  Ali Ergun²  Ugur Keskin²  Ali Seven² 

[1] Department of Obstetrics and Gynecology, Akdeniz University Faculty of Medicine, 07059, Antalya, Turkey;Department of Obstetrics and Gynecology, Gulhane Military Academy, 06018, Ankara, Turkey;

关键词: Clinical Pregnancy;    Body Mass Index Category;    Body Mass Index Group;    Antral Follicle Count;    Normal Weight Woman;   

DOI  :  10.1186/s12905-015-0223-0

 received in 2015-02-04, accepted in 2015-08-12,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to investigate the influence of body mass index (BMI) on the in vitro fertilization (IVF) treatment outcomes in a cohort of women undergoing their first IVF, using an intracytoplasmic sperm injection (ICSI).MethodsThis retrospective cohort study included 298 cycles from women younger than 38 years old undergoing IVF-ICSI at a university infertility clinic. The treatment cycles were divided into three groups according to the BMI of the women involved: normal weight (18.5 ≤ BMI < 25 kg/m2, 164 cycles), overweight (25 ≤ BMI < 30 kg/m2, 70 cycles), and obese (BMI ≥ 30 kg/m2, 64 cycles). The underweight women (BMI < 18.5 kg/m2) were not included in the analysis due to small sample size (n = 22). The patient characteristics and IVF-ICSI treatment outcomes were compared between the BMI groups.ResultsThe total gonadotropin dose (p <0.001) and duration of stimulation (p = 0.008) were significantly higher in the obese group when compared to the normal BMI group. There were no significant differences across the BMI categories for the other IVF-ICSI cycle outcomes measured, including the number of retrieved oocytes, mature oocytes, embryos suitable for transfer, proportion of oocytes fertilized, and cycle cancellation rates (p >0.05 for each). Additionally, clinical pregnancy, spontaneous abortion, and the ongoing pregnancy rates per transfer were found to be comparable between the normal weight, overweight, and obese women (p >0.05 for each).ConclusionObese women might require a significantly higher dose of gonadotropins and longer stimulation durations, without greatly affecting the pregnancy outcomes.

【 授权许可】

CC BY   
© Ozekinci et al. 2015