A double blind randomized trial of wound infiltration with ropivacaine after breast cancer surgery with axillary nodes dissection

BMC Anesthesiology

Research Article

Joelle Berger¹  Axelle Vigneau¹  Anne Salengro¹  Emmanuel Marret¹  Francis Bonnet¹  Emmanuel Barranger²  Roman Rouzier³ 

[1] Department of Anaesthetics and Intensive Care, Tenon Hospital, Assistance Publique hôpitaux de Paris, University Pierre & Marie Curie, Paris VI. 4 rue de la Chine, 75020, Paris, France;Department of Gynaecologic Surgery and Obstetrics, Assistance Publique Hôpitaux de Paris, Université Denis Diderot, Paris VII. 2, rue Ambroise Paré, 75010, Paris, France;Department of Gynaecologic Surgery and Obstetrics, Tenon Hospital, Assistance Publique hôpitaux de Paris, University Pierre & Marie Curie, Paris VI. 4 rue de la Chine, 75020, Paris, France;

关键词: Axillary Node Dissection;    Ropivacaine;    Local Infiltration;    Postoperative Pain Control;    Abduction Angle;   

DOI  :  10.1186/1471-2253-11-23

 received in 2011-03-01, accepted in 2011-11-24,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe effect of local infiltration after breast surgery is controversial. This prospective double blind randomized study sought to document the analgesic effect of local anaesthetic infiltration after breast cancer surgery.MethodsPatients scheduled for mastectomy or tumorectomy and axillary nodes dissection had immediate postoperative infiltration of the surgical wound with 20 ml of ropivacaine 7.5 mg.ml-1 or isotonic saline. Pain was assessed on a visual analogue scale at H2, H4, H6, H12, H24, H72, and at 2 month, at rest and on mobilization of the arm. Patient'comfort was evaluated with numerical 0-3 scales for fatigue, quality of sleep, state of mood, social function and activity.ResultsTwenty-two and 24 patients were included in the ropivacaine and saline groups respectively. Postoperative pain was lower at rest and on mobilization at 2, 4 and 6 hour after surgery in the ropivacaine group. No other difference in pain intensity and patient 'comfort scoring was documented during the first 3 postoperative days. Patients did not differ at 2 month for pain and comfort scores.ConclusionSingle shot infiltration with ropivacaine transiently improves postoperative pain control after breast cancer surgery.Trial registration numberNCT01404377

【 授权许可】

Unknown   
© Vigneau et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.