Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy

BMC Urology

Research Article

Kevin J Wu¹  Alexander S Parker²  Nancy Diehl²  Michelle L Arnold²  Steve Ames³  David D Thiel⁴ 

[1] Department of Anatomic Pathology, 4500 San Pablo Road, 32224, Jacksonville, FL, USA;Department of Health Sciences Research, 4500 San Pablo Road, 32224, Jacksonville, FL, USA;Department of Medicine at Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA;Department of Urology, 4500 San Pablo Road, 32224, Jacksonville, FL, USA;

关键词: Kidney cancer;    Quality of life;    Radical nephrectomy;    Nephron-sparing surgery;   

DOI  :  10.1186/1471-2490-13-52

 received in 2013-07-26, accepted in 2013-10-11,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundTo compare demographics, pathologic features, performance scores, comorbidities, symptoms and responses to quality of life (QoL) surveys between nephron-sparing surgery (NSS) and radical nephrectomy (RN) patients prior to surgical intervention. Previous investigators have compared QoL outcomes for patients undergoing RN and NSS; however, there are limited data comparing QoL-related characteristics at baseline between these groups.MethodsWe identified 144 patients with localized RCC who underwent either NSS (n = 71) or RN (n = 73) between May ‘07-November ‘12. We abstracted baseline data on demographic and clinic-pathologic variables as well as responses to the SF-36 and FACT-G surveys from our prospective registry. We amended the FACT-G with 8 additional questions designed to address RCC-specific QoL. For comparisons between the two groups, we employed Wilcoxon rank-sum and Fisher's Exact tests where appropriate.ResultsWe observed RN patients to have more aggressive pathology. We noted no difference in performance scores between the two groups; however, RN patients were more likely to have higher Charlson scores (p = 0.022) and various symptoms at presentation (all p <0.001). For the QoL surveys, we did not observe differences on the FACT-G; however, we noted evidence of differential scores between the two groups on specific domains of the SF-36 (e.g. Mental Health; p 0.022) and the RCC-specific QoL questions added to the FACT-G.ConclusionsWe report baseline differences between RN and NSS patients on clinico-pathologic as well as QoL-related metrics. As issues of survivorship become increasingly important, our results underscore the need to consider baseline status in evaluations of QoL-related outcomes for patients undergoing surgery for RCC.

【 授权许可】

Unknown   
© Arnold et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.