A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis

BMC Psychiatry

Research Article

Ragnar Nesvåg¹  Akiah O. Berg²  Kristin L. Romm²  Ole A. Andreassen²  Carmen Simonsen²  Ann Færden²  Ingrid Melle²  Monica Aas²  Ingrid Agartz³  Sofie R. Aminoff⁴ 

[1] Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway;Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, PO Box 4956, Bygg 49, Ullevål sykehus, 0424, Nydalen, Oslo, Norway;Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, PO Box 4956, Bygg 49, Ullevål sykehus, 0424, Nydalen, Oslo, Norway;Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway;Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, PO Box 4956, Bygg 49, Ullevål sykehus, 0424, Nydalen, Oslo, Norway;Department of Specialized Inpatient Treatment, Division of Mental Health Services, Akershus University Hospital, Oslo, Norway;

关键词: Emotional Abuse;    Childhood Trauma;    Young Mania Rate Scale;    Emotional Neglect;    Childhood Trauma Questionnaire;   

DOI  :  10.1186/s12888-016-0827-4

 received in 2015-05-23, accepted in 2016-04-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to investigate whether childhood trauma was associated with more severe clinical features in patients with first-episode psychosis, both at the initial assessment and after one year.MethodsNinety-six patients with a first-episode of a DSM-IV diagnosis of psychosis, in addition to 264 healthy controls from the same catchment area, were recruited to the TOP NORMENT study. A history of childhood trauma was obtained using the Childhood Trauma Questionnaire (CTQ). Function and symptom severity were measured using the Global Assessment of Functioning (GAF) Scale divided into function (GAF-F) and symptoms (GAF-S), the Positive and Negative Syndrome Scale (PANSS) and the Young Mania Rating Scale (YMRS). All clinical assessments were completed at two time points: At an initial assessment within the first year of initiating treatment for psychosis and after one year.ResultsChildhood trauma was associated with significantly reduced global functioning and more severe clinical symptoms at both baseline and follow-up, whereas emotional neglect was associated with a significantly reduced improvement rate for global functioning (GAF-F) over the follow-up period.ConclusionOur data indicate that patients with first-episode psychosis who report a history of childhood trauma constitute a subgroup characterized by more severe clinical features over the first year of treatment, as well as slower improvement rates.

【 授权许可】

CC BY   
© Aas et al. 2016