Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia

BMC Nephrology

Research Article

Karen E. Itokua¹  René M. Ngiyulu¹  Jean Lambert Gini¹  Pépé M. Ekulu¹  Michel N. Aloni¹  Pierre Z. Akilimali²  Augustin L. Longo³  Yannick M. Engole³  Nazaire M. Nseka³  François M. Kajingulu³  François B. Lepira³  Vieux M. Mokoli³  Justine B. Bukabau³  Ernest K. Sumaili³  Yannick M. Nlandu³  Chantal V. Zinga³  Jean Robert Makulo⁴ 

[1]Division of Hematology, Oncology and Nephrology, Department of Pediatric, University of Kinshasa Hospital, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

[2]Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

[3]Nephrology Unit, Department of Internal Medicine, University of Kinshasa Hospital, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

[4]Nephrology Unit, Department of Internal Medicine, University of Kinshasa Hospital, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

[5]Faculty of Medicine, University of Kinshasa Hospital, Kinshasa, Democratic Republic of the Congo

关键词: Sickle cell anemia;    Albuminuria;    GPx;    Cu-Zn SOD;    Lactate dehydrogenase;    Inflammation;   

DOI  :  10.1186/s12882-016-0398-0

 received in 2016-02-25, accepted in 2016-11-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundOxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes.MethodsWe consecutively recruited Steady state children aged between 2 and 18 years old with established diagnosis of homozygous SCA in two hospitals of Kinshasa/DR Congo. The relationship between Urinary Albumin Creatinine Ratio (UACR) and other variables of interest (age, systolic blood pressure, diastolic blood pressure, plasma GPx and Cu-Zn SOD, free plasmatic hemoglobin, LDH, indirect bilirubin, white blood cells (WBC), percentage of fetal hemoglobin, serum iron, ferritin, CRP) was analyzed by Bivariate correlation (Pearson’s correlation coefficient). Microalbuminuria was defined by urine albumin/creatinine ratio between 30 and 299 mg/g.ResultsSeventy Steady state Black African children with SCA (56% boys; average age 9.9 ± 4.3 years; 53% receiving hydroxyurea) were selected. Prevalence of microalbuminuria was 11.8%. LDH (r = 0.260; p = 0.033) and WBC count (r = 0.264; p = 0.033) were positively correlated with UACR whereas GPx (− 0.328; p = 0.007) and Cu-Zn SOD (− 0.210; p = 0.091) were negatively correlated with UACR.ConclusionsAlbuminuria is associated with decreased antioxidant capacity and increased levels of markers of hemolysis and inflammation. Therefore, strategies targeting the reduction of sickling and subsequent hemolysis, oxidative stress and inflammation could help preventing or at least delaying the progression of kidney disease in SCA children.

【 授权许可】

CC BY   
© The Author(s). 2016