Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

BMC Gastroenterology

Research Article

Lei Liu¹  Yue Qi¹  Wenli Kong¹  Huan Wang¹  Yu Pan¹  Xiumei Chi²  Xiuzhu Gao²  Hongqin Xu²  Xiaomei Wang²  Ruihong Wu²  Junqi Niu³  Limei Qu⁴ 

[1] Department of Hepatology, First Hospital of Jilin University, Jilin University, 130021, Changchun, China;Department of Hepatology, First Hospital of Jilin University, Jilin University, 130021, Changchun, China;Jilin Province Key Laboratory of Infectious Diseases, Laboratory of Molecular Virology, 130061, Changchun, China;Department of Hepatology, First Hospital of Jilin University, Jilin University, 130021, Changchun, China;Ministry of Education Key Laboratory of Zoonosis, 130061, Changchun, China;Jilin Province Key Laboratory of Infectious Diseases, Laboratory of Molecular Virology, 130061, Changchun, China;Department of Pathology, First Hospital of Jilin University, Jilin University, 130021, Changchun, China;

关键词: Chronic hepatitis C;    Liver fibrosis;    Mac-2 Binding Protein Glycosylation isomer;    Cirrhosis;   

DOI  :  10.1186/s12876-017-0618-5

 received in 2016-10-19, accepted in 2017-05-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis stages in Chinese patients with chronic hepatitis C infection.MethodsSerum M2BPGi levels were evaluated in 680 patients with chronic hepatitis C and 164 healthy controls who underwent the Fibro Scan® test of liver fibrosis. The diagnostic accuracy of serum M2BPGi values was compared to that of other fibrosis markers, including Fibro Scan®, the aspartate transaminase to platelet ratio index (APRI), the fibrosis index based on four factors (FIB4), and the gamma-glutamyltranspeptidase to platelet ratio (GPR).ResultsAmong the chronic hepatitis C patients, the median serum M2BPGi level increased with increasing fibrosis score as follows: 0.88 (≤F2), 1.70 (F2/F3), and 5.68 (cirrhosis). M2BPGi concentrations could also distinguish between healthy controls (0.38 ± 0.24) and hepatitis C patients (1.57 ± 2.28). After adjusting for potential confounders, M2BPGi was the most significant factor associated with the liver stiffness measurement (effect size = 0.275, P < 0.001). The optimum cutoff values of serum M2BPGi for patients with F2 and F4 were 0.945 and 1.355, respectively. The area under the curve of serum M2BPGi for prediction of significant fibrosis (F ≥ 4) using was comparable to that of APRI (0.892 vs. 0.873), while it was superior to that of other alternative markers, including FIB4 (0.818) and GPR (0.851). Compared with other non-invasive markers, M2BPGi had the greatest specificity for diagnosing cirrhosis and cirrhosis in hepatitis C patients.ConclusionsOur results suggest that the level of serum M2BPGi would be a simple and reliable diagnostic tool for identifying liver fibrosis stage in Chinese patients with chronic hepatitis.

【 授权许可】

CC BY   
© The Author(s). 2017